Publications

NCBI list of publications

1. Kauffman ZJ, Koesser K, Helzer KT, Sharifi MN, Heninger E, Li C, Juang DS, Jarrard DF, Zhao SG, Haffner MC, Beebe DJ, Lang JM, Sperger JM. Lossless Altered Histone Modification Analysis System (LAHMAS). Lab Chip. 2025 Aug 5;25(16):4059-4070. doi: 10.1039/d5lc00060b. PMID: 40620045.
2. Sánchez-de-Diego C, Yada RC, Sethakorn N, Geiger PG, Ding AB, Heninger E, Ahmed F, Virumbrales-Muñoz M, Lupsa N, Bartels E, Stewart K, Ponik SM, Sharifi MN, Lang JM, Beebe DJ, Kerr SC. Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response. Commun Biol. 2025 Jul 1;8(1):961. doi: 10.1038/s42003-025-08384-2. PMID: 40596459; PMCID: PMC12218145.
3. Liang NW, Milesh L, Buttram KN, Park JL, Zhang J, Summey LA, Franck C, Beebe DJ, Le HD, Li C. Under-oil neuronal cell culture: Enhanced system stability, yield, and modulated oxygen environment. J Neurosci Methods. 2025 Oct;422:110511. doi: 10.1016/j.jneumeth.2025.110511. Epub 2025 Jun 2. PMID: 40466868.
4. Babatunde KA, Babatunde OF, Ahmed A, Salgado-Pabon W, Beebe DJ, Kerr SC. Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing. Adv Sci (Weinh). 2025 May 31:e01036. doi: 10.1002/advs.202501036. Epub ahead of print. PMID: 40448602.
5. Schrope JH, Horn A, Lazorchak K, Tinnen CW, Stevens JJ, Farooqui M, Robertson T, Li J, Bennin D, Juang T, Ahmed A, Li C, Huttenlocher A, Beebe DJ. Confinement by Liquid-Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb-Based Migration. Adv Sci (Weinh). 2025 Jun;12(21):e2414024. doi: 10.1002/advs.202414024. Epub 2025 Mar 28. PMID: 40151891; PMCID: PMC12140350.
6. Ramírez-Flores CJ, Hryckowian ND, Gale AN, Babatunde KA, Lares M, Beebe DJ, Kerr SC, Knoll LJ. Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system. PLoS Negl Trop Dis. 2025 Feb 4;19(2):e0012855. doi: 10.1371/journal.pntd.0012855. PMID: 39903779; PMCID: PMC12136440.
7. Magesh S, Schrope JH, Soto NM, Li C, Hurley AI, Huttenlocher A, Beebe DJ, Handelsman J. Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species. Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2417327122. doi: 10.1073/pnas.2417327122. Epub 2025 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2504171122. doi: 10.1073/pnas.2504171122. PMID: 39899715; PMCID: PMC11831133.
8. Juang DS, Wightman WE, Lozano GL, Juang TD, Barkal LJ, Yu J, Garavito MF, Hurley A, Venturelli OS, Handelsman J, Beebe DJ. Microbial community interactions on a chip. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2403510121. doi: 10.1073/pnas.2403510121. Epub 2024 Sep 17. PMID: 39288179; PMCID: PMC11441501.
9. Babatunde KA, Datta R, Hendrikse NW, Ayuso JM, Huttenlocher A, Skala MC, Beebe DJ, Kerr SC. Naive primary neutrophils play a dual role in the tumor microenvironment. iScience. 2024 Aug 2;27(9):110632. doi: 10.1016/j.isci.2024.110632. PMID: 39246449; PMCID: PMC11379674.
10. Juang TD, Riendeau J, Geiger PG, Datta R, Lares M, Yada RC, Singh AM, Seroogy CM, Gern JE, Skala MC, Beebe DJ, Kerr SC. Micro blood analysis technology (μBAT): multiplexed analysis of neutrophil phenotype and function from microliter whole blood samples. Lab Chip. 2024 Aug 20;24(17):4198-4210. doi: 10.1039/d4lc00333k. PMID: 39104301; PMCID: PMC11335436.
11. Liang NW, Wilson C, Davis B, Wolf I, Qyli T, Moy J, Beebe DJ, Schnapp LM, Kerr SC, Faust HE. Modeling lung endothelial dysfunction in sepsis-associated ARDS using a microphysiological system. Physiol Rep. 2024 Jul;12(13):e16134. doi: 10.14814/phy2.16134. PMID: 38981846; PMCID: PMC11233195.
12. Giese MA, Bennin DA, Schoen TJ, Peterson AN, Schrope JH, Brand J, Jung HS, Keller NP, Beebe DJ, Dinh HQ, Slukvin II, Huttenlocher A. PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function. J Leukoc Biol. 2024 Jun 28;116(1):118-131. doi: 10.1093/jleuko/qiae039. PMID: 38417030; PMCID: PMC11212797.
13. Rengarajan A, Goldblatt HE, Beebe DJ, Virumbrales-Muñoz M, Boeldt DS. Immune cells and inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system. Lab Chip. 2024 Mar 12;24(6):1808-1820. doi: 10.1039/d3lc00824j. PMID: 38363157; PMCID: PMC11022267.
14. Magesh S, Hurley AI, Nepper JF, Chevrette MG, Schrope JH, Li C, Beebe DJ, Handelsman J. Surface colonization by Flavobacterium johnsoniae promotes its survival in a model microbial community. mBio. 2024 Mar 13;15(3):e0342823. doi: 10.1128/mbio.03428-23. Epub 2024 Feb 8. PMID: 38329367; PMCID: PMC10936215.
15. Chen Q, Zhai H, Beebe DJ, Li C, Wang B. Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions. Nat Commun. 2024 Feb 7;15(1):1155. doi: 10.1038/s41467-024-45076-7. PMID: 38326343; PMCID: PMC10850056.
16. Li C, Farooqui M, Yada RC, Cai JB, Huttenlocher A, Beebe DJ. The effect of whole blood logistics on neutrophil non-specific activation and kinetics ex vivo. Sci Rep. 2024 Jan 30;14(1):2543. doi: 10.1038/s41598-023-50813-x. PMID: 38291060; PMCID: PMC10828393.
17. Peterson A, Bennin D, Lasarev M, Chini J, Beebe DJ, Huttenlocher A. Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B. J Cell Sci. 2024 Feb 1;137(3):jcs261774. doi: 10.1242/jcs.261774. Epub 2024 Feb 12. PMID: 38224139; PMCID: PMC10911274.
18. Abizanda-Campo S, Virumbrales-Muñoz M, Humayun M, Marmol I, Beebe DJ, Ochoa I, Oliván S, Ayuso JM. Microphysiological systems for solid tumor immunotherapy: opportunities and challenges. Microsyst Nanoeng. 2023 Dec 15;9:154. doi: 10.1038/s41378-023-00616-x. PMID: 38106674; PMCID: PMC10724276.
19. Schrope JH, Horn A, Farooqui M, Lazorchak K, Li J, Tinnen C, Stevens JJ, Bennin D, Robertson T, Juang T, Li C, Huttenlocher A, Beebe DJ. Liquid-liquid interfaces enable tunable cell confinement to recapitulate surrounding tissue deformations during neutrophil interstitial migration in vivo. bioRxiv [Preprint]. 2023 Dec 9:2023.06.14.544898. doi: 10.1101/2023.06.14.544898. PMID: 38106211; PMCID: PMC10723256.
20. Liang NW, Wilson C, Davis B, Wolf I, Qyli T, Moy J, Beebe DJ, Schnapp LM, Kerr SC, Faust HE. Modeling Sepsis-Associated ARDS Using a Lung Endothelial Microphysiological System. bioRxiv [Preprint]. 2023 Oct 10:2023.10.10.561102. doi: 10.1101/2023.10.10.561102. Update in: Physiol Rep. 2024 Jul;12(13):e16134. doi: 10.14814/phy2.16134. PMID: 37873450; PMCID: PMC10592774.
21. Ayuso JM, Farooqui M, Virumbrales-Muñoz M, Denecke K, Rehman S, Schmitz R, Guerrero JF, Sanchez-de-Diego C, Campo SA, Maly EM, Forsberg MH, Kerr SC, Striker R, Sherer NM, Harari PM, Capitini CM, Skala MC, Beebe DJ. Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nat Commun. 2023 Oct 21;14(1):6681. doi: 10.1038/s41467-023-41625-8. Erratum in: Nat Commun. 2023 Nov 10;14(1):7292. doi: 10.1038/s41467-023-43057-w. PMID: 37865647; PMCID: PMC10590421.
22. Sanchez-de-Diego C, Virumbrales-Muñoz M, Hermes B, Juang TD, Juang DS, Riendeau J, Guzman EC, Reed-McBain CA, Abizanda-Campo S, Patel J, Hess NJ, Skala MC, Beebe DJ, Ayuso JM. Griddient: a microfluidic array to generate reconfigurable gradients on-demand for spatial biology applications. Commun Biol. 2023 Sep 9;6(1):925. doi: 10.1038/s42003-023-05282-3. PMID: 37689746; PMCID: PMC10492845.
23. Li C, McCrone S, Warrick JW, Andes DR, Hite Z, Volk CF, Rose WE, Beebe DJ. Under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testing. Lab Chip. 2023 Apr 12;23(8):2005-2015. doi10.1039/d3lc00066d. PMID: 36883560.
24. McMinn PH, Ahmed A, Huttenlocher A, Beebe DJ, Kerr SC. The lymphatic endothelium-derived follistatin: activin A axis regulates neutrophil motility in response to Pseudomonas aeruginosa. Integr Biol (Camb). 2023 Apr 11;15:zyad003. doi: 10.1093/intbio/zyad003. PMID: 36781971.
25. Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W, Beltran H, Choueiri TK, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE, Taplin ME, Lang JM. A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer. J ClinInvest. 2022 Nov 1;132(21):e161858. doi: 10.1172/JCI161858. PMID: 36317634; PMCID: PMC9621140.
26. Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM. Enhanced Ribonucleoprotein Immunoprecipitation (RIP) Technique for the Identification of mRNA Species in Ribonucleoprotein Complexes. Bio Protoc. 2022 Oct 5;12(19):e4526. doi: 10.21769/BioProtoc.4526. PMID: 36313200; PMCID: PMC9548516.
27. Sethakorn N, Heninger E, Breneman MT, Recchia E, Ding AB, Jarrard DF, Hematti P, Beebe DJ, Kosoff D. Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform. FASEB J. 2022 Oct;36(10):e22540. doi: 10.1096/fj.202200684RR. PMID: 36083096; PMCID: PMC9476232.
28. Rodems TS, Heninger E, Stahlfeld CN, Gilsdorf CS, Carlson KN, Kircher MR, Singh A, Krueger TEG, Beebe DJ, Jarrard DF, McNeel DG, Haffner MC, Lang JM. Reversible epigenetic alterations regulate class I HLA loss in prostate cancer. Commun Biol. 2022 Sep 1;5(1):897. doi: 10.1038/s42003-022-03843-6. PMID: 36050516; PMCID: PMC9437063.
29. Simitian G, Virumbrales-Munoz M, Sanchez-de-Diego C, Beebe DJ, Kosoff D. Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians. Lab Chip. 2022 Sep 27;22(19):3618-3636. doi:10.1039/d2lc00352j. PMID: 36047330; PMCID: PMC9530010.
30. Juang DS, Juang TD, Dudley DM, Newman CM, Accola MA, Rehrauer WM, Friedrich TC, O’Connor DH, Beebe DJ. Oil immersed lossless total analysis system for integrated RNA extraction and detection of SARS-CoV-2. Nat Commun. 2021 Jul 14;12(1):4317.
31. Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O’Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin N, Burkard. Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.Mol Cancer Ther. 2021 Dec;20(12):2553-2567. doi: 10.1158/1535-7163.MCT-21-0195. Epub 2021 Sep 28.
32. Li C, Hurley A, Hu W, Warrick JW, Lozano GL, Ayuso JM, Pan W, Handelsman J, Beebe DJ. Social motility of biofilm-like microcolonies in a gliding bacterium. Nat Commun. 2021 Sep 29;12(1):5700. doi: 10.1038/s41467-021-25408-7.
33. Babatunde KA, Ayuso JM, Kerr SC, Huttenlocher A, Beebe DJ. Microfluidic Systems to Study Neutrophil Forward and Reverse Migration. Front Immunol. 2021 Nov 24;12:781535. doi: 10.3389/fimmu.2021.781535. eCollection 2021.
34. Lugo-Cintrón KM, Ayuso JM, Humayun M, Gong MM, Kerr SC, Ponik SM, Harari PM, Virumbrales-Muñoz M, Beebe DJ. Primary head and neck tumour-derived fibroblasts promote lymphangiogenesis in a lymphatic organotypic co-culture model. 2021 Nov;73:103634. doi: 10.1016/j.ebiom.2021.103634. Epub 2021 Oct 18.
35. Heninger E, Kosoff D, Rodems TS, Sethakorn N, Singh A, Gungurthi H, Carlson KN, Yang B, Gilsdorf C, Pasch CA, Deming DA, Ellis L, Beebe DJ, Jarrard DF, Lang JM. Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling. Med Oncol. 2021 Sep 28;38(11):135.
36. van Steen ACI, Kempers L, Schoppmeyer R, Blokker M, Beebe DJ, Nolte MA, van Buul JD. Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix. J Cell Sci. 2021 Nov 1;134(21):jcs258690. doi: 10.1242/jcs.258690. Epub 2021 Nov 4.
37. Park KY, Hefti HO, Liu P, Lugo-Cintrón KM, Kerr SC, Beebe DJ. Immune cell mediated cabozantinib resistance for patients with renal cell carcinoma. Integr Biol (Camb). 2021 Dec 30;13(11):259-268.
38. Sethakorn N, Heninger E, Sánchez-de-Diego C, Ding AB, Yada RC, Kerr SC, Kosoff D, Beebe DJ, Lang JM. Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment. Cancers (Basel). 2022 Feb 1;14(3):757. doi: 10.3390/cancers14030757.
39. Vitek RA, Huang W, Geiger PG, Heninger E, Lang JM, Jarrard DF, Beebe DJ, Johnson BP. Fresh tissue procurement and preparation for multicompartment and multimodal analysis of the prostate tumor microenvironment. 2022 May;82(7):836-849. doi: 10.1002/pros.24326. Epub 2022 Feb 28.
40. Virumbrales-Muñoz M, Ayuso JM, Loken JR, Denecke KM, Rehman S, Skala MC, Abel EJ, Beebe DJ. Microphysiological model of renal cell carcinoma to inform anti-angiogenic therapy. 2022 Apr;283:121454. doi: 10.1016/j.biomaterials.2022.121454. Epub 2022 Mar 11.
41. Shapiro DD, Virumbrales-Muñoz M, Beebe DJ, Abel EJ. Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics. Front Oncol. 2022 Apr 7;12:871252. doi: 10.3389/fonc.2022.871252. eCollection 2022.
42. Rodems TS, Juang DS, Stahlfeld CN, Gilsdorf CS, Krueger TEG, Heninger E, Zhao SG, Sperger JM, Beebe DJ, Haffner MC, Lang JM. SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples. Clin Epigenetics. 2022 Mar 10;14(1):37. doi: 10.1186/s13148-022-01252-4.
43. Fakhraldeen SA, Berry SM, Beebe DJ, Roopra A, Bisbach CM, Spiegelman VS, Niemi NM, Alexander CM. Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells. J Biol Chem. 2022 Mar;298(3):101649. doi: 10.1016/j.jbc.2022.101649. Epub 2022 Jan 29.
44. Schehr JL, Sethakorn N, Schultz ZD, Hernandez CI, Bade RM, Eyzaguirre D, Singh A, Niles DJ, Henderson L, Warrick JW, Berry SM, Sundling KE, Beebe DJ, Leal TA, Lang JM. Analytical validation and initial clinical testing of quantitative microscopic evaluation for PD-L1 and HLA I expression on circulating tumor cells from patients with non-small cell lung cancer. Biomark Res. 2022 Apr 25;10(1):26. doi: 10.1186/s40364-022-00370-8.
45. Juang DS, Lang JM, Beebe DJ. Volumeless reagent delivery: a liquid handling method for adding reagents to microscale droplets without increasing volume. Lab Chip. 2022 Jan 18;22(2):286-295. doi: 10.1039/d1lc00906k.
46. Sadangi S, Milosavljevic K, Castro-Perez E, Lares M, Singh M, Altameemi S, Beebe DJ, Ayuso JM, Setaluri V Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes. Cancers (Basel). 2022 Feb 27;14(5):1233. doi: 10.3390/cancers14051233.
47. Li C, Humayun M, Walker GM, Park KY, Connors B, Feng J, Pellitteri Hahn MC, Scarlett CO, Li J, Feng Y, Clark RL, Hefti H, Schrope J, Venturelli OS, Beebe DJ. Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach for Microscale Cell Culture. Adv Sci (Weinh). 2022 Apr;9(10):e2104510. doi: 10.1002/advs.202104510. Epub 2022 Feb 4.
48. Juang DS, Juang TD, Dudley DM, Newman CM, Accola MA, Rehrauer WM, Friedrich TC, O’Connor DH, Beebe DJ. Oil immersed lossless total analysis system for integrated RNA extraction and detection of SARS-CoV-2. Nat Commun. 2021 Jul 14;12(1):4317. doi: 10.1038/s41467-021-24463-4. PMID: 34262053; PMCID:PMC8280165.

49. Hind LE, Giese MA, Schoen TJ, Beebe DJ, Keller N, Huttenlocher A. Immune Cell Paracrine Signaling Drives the Neutrophil Response to <i>A. fumigatus</i> in an Infection-on-a-Chip Model. Cell Mol Bioeng. 2020 Oct 13;14(2):133-145. doi: 10.1007/s12195-020-00655-8. PMID: 33868496; PMCID: PMC8010091.

50. Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Basu H, Beebe DJ. A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment. Integr Biol (Camb). 2021 Apr 20;13(4):87-97. doi: 10.1093/intbio/zyab004. PMID: 33822934.

51. Johnson BP, Vitek RA, Morgan MM, Fink DM, Beames TG, Geiger PG, Beebe DJ, Lipinski RJ. A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development. Front Cell Dev Biol. 2021 Feb 9; 9:621442. doi: 10.3389/fcell.2021.621442. PMID: 33634122; PMCID: PMC7900501.

52. Bade RM, Schehr JL, Emamekhoo H, Gibbs BK, Rodems TS, Mannino MC, Desotelle JA, Heninger E, Stahlfeld CN, Sperger JM, Singh A, Wolfe SK, Niles DJ, Arafat W, Steinharter JA, Jason Abel E, Beebe DJ, Wei XX, McKay RR, Choueri TK, Lang JM. Development and initial clinical testing of a multiplexed circulating tumor cell assay in patients with clear cell renal cell carcinoma. Mol Oncol. 2021 Feb 19. doi: 10.1002/1878-0261.12931. Epub ahead of print. PMID: 33604999.

53. Ayuso JM, Rehman S, Virumbrales-Munoz M, McMinn PH, Geiger P, Fitzgerald C, Heaster T, Skala MC, Beebe DJ. Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion. Sci Adv. 2021 Feb 17;7(8):eabc2331. doi: 10.1126/sciadv.abc2331. PMID: 33597234; PMCID: PMC7888951.

54. Humayun M, Ayuso JM, Brenneke RA, Virumbrales-Muñoz M, Lugo-Cintrón K, Kerr S, Ponik SM, Beebe DJ. Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model. Biomaterials. 2021 Mar;270:120640. doi: 10.1016/j.biomaterials.2020.120640. Epub 2021 Feb 6. PMID: 33592387.

55. Ayuso JM, Sadangi S, Lares M, Rehman S, Humayun M, Denecke KM, Skala MC, Beebe DJ, Setaluri V. Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism. Lab Chip. 2021 Mar 21;21(6):1139-1149. doi: 10.1039/d0lc00988a. Epub 2021 Feb 3. PMID: 33533390; PMCID: PMC7990711.

56. Ayuso JM, Park KY, Virumbrales-Muñoz M, Beebe DJ. Toward improved <i>in vitro</i> models of human cancer. APL Bioeng. 2021 Jan 21;5(1):010902. doi: 10.1063/5.0026857. PMID: 33532672; PMCID: PMC7822630.

57. Ayuso JM, Rehman S, Farooqui M, Virumbrales-Muñoz M, Setaluri V, Skala MC, Beebe DJ. Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. Int J Mol Sci. 2020 Nov 28;21(23):9075. doi: 10.3390/ijms21239075. PMID: 33260673; PMCID: PMC7730115.

58. Virumbrales-Muñoz M, Chen J, Ayuso JM, Lee Moonhee, Abel, Beebe DJ. Organotypic primary blood vessel models of clear cell renal cell carcinoma for single-patient clinical trials. Lab Chip. 2020 Oct 26.doi: 10.1039/d0lc00252f. Online ahead of print.
59. Heaster TM, Humayun M, Yu J, Beebe DJ, Skala MC. Autoflourescence imaging of 3D tumor-macrophage microscale cultures resolves spatial and temporal dynamics of macrophage metabolism. Cancer Res. 2020 Oct 22;canres.0831.2020. doi: 10.1158/0008-5472.CAN-20-0831. Online ahead of print.
60. Kerr SC, Morgan MM, Gillette AA, Livingston MK, Lugo-Cintron KM, Favreau PF, Florek L, Johnson BP, Lang JM, Skala MC, Beebe DJ. A bioengineered organotypic prostate model for the study of tumor microenvironment-induced immune cell activation. Integr Biol (Camb). 2020 Oct 16;12(10):250-262. doi: 10.1093/intbio/zyaa020.
61. Virumbrales-Muñoz M, Ayuso JM, Gong MM, Humayun M, Livingston MK, Lugo-Cintrón KM, McMinn P, Álvarez-García YR, Beebe DJ. Microfluidic lumen-based systems for advancing tubular organ modeling. Chem Soc Rev. 2020 Aug 6. doi: 10.1039/d0cs00705f. Online ahead of print.PMID: 32760967
62. Kaushik G, Gupta K, Harms V, Torr E, Evans J, Johnson HJ, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D, Uhl P, Johnson BP, Palecek SP, Beebe DJ, Thomson JA, Daly WT, Murphy WL. Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity. Adv Healthc Mater. 2020 Jul 1:e2000825. doi: 10.1002/adhm.202000825. Online ahead of print.PMID: 32613760
63. McMinn P, Guckenberger DJ, Beebe DJ. Induced Pluripotent Stem Cells on a Chip: A Self-Contained, Accessible, Pipette-less iPSC Culturing and Differentiation Kit. SLAS Technol. 2020 Jun 19:2472630320921173. doi: 10.1177/2472630320921173. Online ahead of print.
64. Li C, Hite Z, Warrick JW, Li J, Geller SH, Trantow VG, McClean MN, Beebe DJ. Under oil open-channel microfluidics empowered by exclusive liquid repellency. Sci Adv. 2020 Apr 17;6(16):eaay9919. doi: 10.1126/sciadv.aay9919. eCollection 2020 Apr.PMID: 32494607
65. Lugo-Cintrón KM, Gong MM, Ayuso JM, Tomko LA, Beebe DJ, Virumbrales-Muñoz M, Ponik SM. Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration Through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model. Cancers (Basel). 2020 May 6;12(5):1173. doi: 10.3390/cancers12051173.PMID: 32384738
66. Lugo-Cintrón KM, Ayuso JM, White BR, Harari PM, Ponik SM, Beebe DJ, Gong MM, Virumbrales-Muñoz M. Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment. Lab Chip. 2020 May 7;20(9):1586-1600. doi: 10.1039/d0lc00099j. Epub 2020 Apr 16.PMID: 32297896
67. Morgan MM, Schuler LA, Ciciliano JC, Johnson BP, Alarid ET, Beebe DJ. Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro. Integr Biol (Camb). 2020 Mar 6;12(2):21-33. doi: 10.1093/intbio/zyaa002.PMID: 32118264
68. Whitt J, Hong WS, Telange RR, Lin CP, Bibb J, Beebe DJ, Chen H, Jaskula-Sztul R. Non-toxic fragment of botulinum neurotoxin type A and monomethyl auristatin E conjugate for targeted therapy for neuroendocrine tumors. Cancer Gene Ther. 2020 Feb 7. doi: 10.1038/s41417-020-0167-x. [Epub ahead of print] PMID:32029905
69. Tokar JJ, Stahlfield CN, Sperger JM, Niles DJ, Beebe DJ, Lang, JM, Warrick JW. Pairing Microwell Arrays with an Affordable, Semiautomated Single Cell Aspirator for the Interrogation of Circulating Tumor Cell Heterogeneity. SLAS Technol. 2020 Jan 26:2472630319898146. doi: 10.1177/2472630319898146. [Epub ahead of print]
70. Ayuso JM, Gong MM, Skala MC, Harari PM, Beebe DJ. Human Tumor-Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Adv.Healthc. Mater. 2020 Jan1. e1900925. doi: 10.1002/adhm.201900925. [Epub ahead of print]
71. Livingston MK, Morgan MM, Daly WT,m Murphy WL, Johnson BP, Beebe DJ, Virumbrales-Munoz M. Evaluation of PEG-based hydrogel influence on estrogen receptor driven responses in MCF7 breast cancer cells. ACS Biomater Sci Eng. 2019;5(11):6089-6098.
72. Virumbrales-Munoz M, Livingston MK, Farooqui M, Skala MC, Beebe DJ, Ayuso JM. Development of a Microfluidic Array to Study Drug Response in Breast Cancer. Molecules. 2019 Nov 30;24(23).
73. McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control. Lab Chip. 2019 Oct 2. doi: 10.1039/c9lc00562e. [Epub ahead of print]
74. Ayuso JM, Virumbrales-Munoz M, McMinn PH, Rehman S, Gomez I, Karim MR, Truttschel R, Wisinski KB, Beebe DJ, Skala MC. Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. Lab Chip. 2019 Sep 11. doi: 10.1039/c9lc00270g. [Epub ahead of print]
75. Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ. Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells. Sci Rep. 2019 Aug 28:9(1):12480. 12480. doi: 10.1038/s41598-019-48764-3.PMID: 31462653.
76. Yu J, Berthier E, Craig A, de Groot TE, Sparks S, Ingram PN, Jarrard DF, Huang W, Beebe DJ, Theberge AB. Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signaling. Nat Biomed Eng. 2019 Aug 19. doi: 10.1038/s41551-019-0421-4. PMID: 31427781
77. Juang DS, Berry SM, Li C, Lang JM, Beebe DJ. Centrifugation-Assisted Immiscible Fluid Filtration for Dual Bioanalyte Extraction. Anal Chem. 2019 Aug 26. doi: 10.1021/acs.analchem.9b02572. PMID: 31411020.
78. Gong MM, Lugo-Cintron KM, White BR, Kerr SC, Harari PM, Beebe DJ. Human organotypic lymphatic vessel model elucidates microenvironment-dependent signaling and barrier function. 2019 Sep;214:119225. doi: 10.1016/j.biomaterials.2019.119225. Epub 2019 May 25. PMID: 31154151.
79. Seenivasan R, Warrick JW, Rodriguez CI, Mattison W, Beebe DJ, Setaluri V, Gunasekaran S. Integrating Electrochemical Immunosensing and Cell Adhesion Technologies for Cancer Cell Detection and Enumeration. Seenivasan R, Warrick JW, Rodriguez CI, Mattison W, Beebe DJ, Setaluri V, Gunasekaran S. Electrochim Acta. 2018 Oct 1;286:205-211. doi: 10.1016/j.electacta.2018.08.005. Epub 2018 Aug 4. PMID: 31130739.
80. Regier MC, Olszewski E, Carter CC, Aitchison JD, Kaushansky A, Davis J, Berthier E, Beebe DJ, Stevens KR. Spatial presentation of biological molecules to cells by localized diffusive transfer. Lab Chip. 2019 Jun 11;19(12):2114-2126. doi: 10.1039/c9lc00122k. PMID: 31111131.
81. Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR. User-defined morphogen patterning for directing human cell fate stratification. Sci Rep. 2019 Apr 23;9(1):6433. doi: 10.1038/s41598-019-42874-8. PMID: 31015521.
82. Morgan MM, Arendt LM, Alarid ET, Beebe DJ, Johnson BP. Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model. FASEB J. 2019 Jul;33(7):8623-8633. doi: 10.1096/fj.201802347RRR. Epub 2019 Apr 19. PMID: 31002529.
83. Li C, Niles DJ, Juang DS, Lang JM, Beebe DJ. Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency. SLAS Technol. 2019 Jun 10:2472630319853219. doi: 10.1177/2472630319853219. [Epub ahead of print]. PMID: 31180792.
84. Virumbrales-Muñoz M, Ayuso JM, Lacueva A, Randelovic T, Livingston MK, Beebe DJ, Oliván S, Pereboom D, Doblare M, Fernández L, Ochoa I. Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling. Sci Rep. 2019 Apr 17;9(1):6199. doi: 10.1038/s41598-019-42529-8. PMID: 30996291.
85. Jiménez-Torres JA, Virumbrales-Muñoz M, Sung KE, Lee MH, Abel EJ, Beebe DJ. Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma. 2019 Apr;42:408-419. doi: 10.1016/j.ebiom.2019.03.026. Epub 2019 Mar 20. PMID: 30902740.
86. Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC. Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. 2018 Dec 12;8(3):1553477. doi: 10.1080/2162402X.2018.1553477. eCollection 2019. PMID: 30723584.
87. Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedo S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ. Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. 2018 Nov;37:144-157. doi: 10.1016/j.ebiom.2018.10.046. Epub 2018 Oct 26. PMID: 30482722.
88. Pezzi HM, Guckenberger DJ, Schehr JL, Rothbauer J, Stahlfeld C, Singh A, Horn S, Schultz ZD, Bade RM, Sperger JM, Berry SM, Lang JM, Beebe DJ. Versatile exclusion-based sample preparation platform for integrated rare cell isolation and analyte extraction. Lab Chip. 2018 Nov 6;18(22):3446-3458. doi: 10.1039/c8lc00620b. PMID: 30334061.
89. Álvarez-García YR, Ramos-Cruz KP, Agostini-Infanzón RJ, Stallcop LE, Beebe DJ, Warrick JW, Domenech M. Open multi-culture platform for simple and flexible study of multi-cell type interactions. Lab Chip. 2018 Oct 9;18(20):3184-3195. doi: 10.1039/c8lc00560e. PMID: 30204194.
90. Li C, Yu J, Schehr J, Berry SM, Leal TA, Lang JM, Beebe DJ. Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing. ACS Appl Mater Interfaces. 2018 May 23;10(20):17065-17070. doi: 10.1021/acsami.8b03627. Epub 2018 May 8.
91. Álvarez-García YR, Ramos-Cruz KP, Agostini-Infanzón RJ, Stallcop LE, Beebe DJ, Warrick JW, Domenech M. Open multi-culture platform for simple and flexible study of multi-cell type interactions. Lab Chip. 2018 Sep 11. doi: 10.1039/c8lc00560e. [Epub ahead of print]. PMID: 30204194
92. Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P. aeruginosa. 2018 Aug 24. pii: blood-2018-05-848465. doi: 10.1182/blood-2018-05-848465. [Epub ahead of print]
93. Kosoff D, Yu J, Suresh V, Beebe DJ, Lang JM. Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems. Lab Chip. 2018 Aug 22. doi: 10.1039/c8lc00431e. [Epub ahead of print]PMID: 30131982
94. Li C, Yu J, Paine P, Juang DS, Berry SM, Beebe DJ. Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis. Lab Chip. 2018 Aug 2. doi: 10.1039/c8lc00584b. PMID 30069559
95. Johnson BP, Vitek RA, Geiger PG, Huang W, Jarrard DF, Lang JM, Beebe DJ. Vital ex vivo tissue labeling and pathology-guided micropunching to characterize cellular heterogeneity in the tissue microenvironment. 2018 Jan 1;64(1):13-19. doi: 10.2144/000114626. PMID: 29384072.
96. Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ.  An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.Adv Healthc Mater. 2018 Jan;7(2). doi: 10/1002/adhm.201700497. PMID 29364596.
97. Poenitzsch Strong AM, Berry SM, Beebe DJ, Li JL, Spiegelman VS. miFAST: A novel and rapid microRNA target capture method.Lab Chip. 2018 Jan 30; 18(3):451-462. doi: 10.1039/c7Ic00724h. PMID 29318250.
98. Stallcop LE, Álvarez-García YR, Reyes-Ramos AM, Ramos-Cruz KP, Morgan MM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW. Razor-printed sticker microdevices for cell-based applications.Lab Chip. 2018 Jan 30;18(3):451-462. doi: 10.1039/c7lc00724h. PMID: 29318250.
99. Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ. Microbial volatile communication in human organotypic lung models.Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4. PMID: 29176665.
100. Pezzi HM, Berry SM, Beebe DJ, Striker R. RNA-mediated TILDA for improved cell capacity and enhanced detection of multiply-spliced HIV RNA.Integr Biol (Camb). 2017 Nov 13;9(11):876-884. doi: 10.1039/c7ib00112f. PMID: 29098230.
101. Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF. Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. PMID: 29073104.
102. Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ. Multikingdom microscale models. PLoS Pathog. 2017 Aug 24; 13(8): e1006424. doi: 10.1371/journal/ppat.1006424. PMID: 28837694.
103. Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttnelocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078. PMID: 28528177
104. Tokar JJ, Warrick JW, Guckenberger DJ, Sperger JM, Lang JM, Ferguson JS, Beebe DJ. Interrogating Bronchoalveolar Lavage Samples via Exclusion-Based Analyte Extraction. SLAS Technol. 2017 Jun 22(3): 348-357. doi: 10.1177/2472630317696780. Epub 2017 Mar 15. PMID: 28298147
105. Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE. The Influence of Biomaterials on Cytokine Production in 3D Cultures. Biomacromolecules. 2017 Mar 13; 18(3): 709-18. doi: 10.1021/acs.biomac.6b01469. Epub 2017 Feb 16. PMID: 28157290
106. Johnson CJ, Cabezas-Olcoz J, Kemien JF, Wang SX, Beebe DJ, Huttenlocher A, Ansari H, Nett JE. The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps. PLoS Pathog. 2016 Sep 13; 12(9)e1005884. doi: 10.1371/journal.ppat.1005884. PMID: 27622514
107. Guckenberger DJ, Pezzi HM, Regier MC, Berry SM, Fawcett K, Barrett K, Beebe DJ. A magnetic system for automated manipulation of paramagnetic particles.Anal Chem. Epub 2016 Sep 6.  PMID: 2759885
108. Jiménez-Torres JA, Beebe DJ, Sung KE. A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment.Methods Mol Biol. 2016;1458:59-69. doi: 10.1007/978-1-4939-3801-8_5. PMID: 2758101
109. Regier MC, Maccoux LJ, Weinberger EM, Regehr KJ, Berry SM, Beebe DJ, Alarid ET.  Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments.Biomed Microdevices. 2016 Aug;18(4):70. doi: 10.1007/s10544-016-0083-x. PMID: 2743232
110. Schehr JL, Schultz ZD, Warrick JW, Guckenberger DJ, Pezzi HM, Sperger JM, Heninger E, Saeed A, Leal T, Mattox K, Traynor AM, Campbell TC, Berry SM, Beebe DJ, Lang JM. High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1. PLoS One. 2016 Jul 26;11(7):e0159397. doi: 10.1371/journal.pone.0159397. eCollection 2016. PMID: 2745954
111. Sperger JM, Strotman LN, Welsh A, Casavant BP, Chalmers Z, Horn S, Heninger E, Thiede S, Tokar J, Gibbs BK, Guckenberger DJ, Carmichael L, Dehm SM, Stephens PJ, Beebe DJ, Berry SM, Lang JM. Integrated analysis of multiple biomarkers from circulating tumor cells enabled by exclusion-based analyte isolation.Clin Cancer Res. 2016 Jul 11. pii: clincanres.1021.2016. [Epub ahead of print] PMID: 2740124
112. Regier MC, Alarid ET, Beebe DJ. Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.Integr Biol (Camb). 2016 Jun 13;8(6):684-92. doi: 10.1039/c6ib00001k. Epub 2016 Apr 21. PubMed PMID: 27097801
113. Berry SM, Pezzi HM, LaVanway AJ, Guckenberger DJ, Anderson MA, Beebe DJ. AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions.ACS Appl Mater Interfaces. 2016 Jun 10. [Epub ahead of print] PubMed Central PMCID: 5058634.
114. Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ. Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.Pharmacol Ther. 2016 May 21. pii: S0163-7258(16)30078-X. doi: 10.1016/j.pharmthera.2016.05.007. [Epub ahead of print] Review. PubMed PMID: 27218886.
115. Barkal LJ, Walsh NM, Botts MR, Beebe DJ, Hull CM. Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination.Integr Biol (Camb). 2016 May 16;8(5):603-15. doi: 10.1039/c6ib00012f. Epub 2016 Mar 30. PubMed PMID: 27026574; PubMed Central PMCID: PMC4868663
116. Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels.Acta Biomater. 2016. doi: 10.1016/j.actbio.2016.03.001. PubMed PMID: 26945632
117. Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang CC, Beebe DJ, Keller NP, Berthier E. Microbial metabolomics in open microscale platforms.Nat Commun. 2016 Feb 4;7:10610. doi: 10.1038/ncomms10610. PubMed PMID: 26842393.
118. Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW, Guckenberger DJ, Huttenlocher A, Beebe DJ. Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.Integr Biol (Camb). 2016 Feb 15;8(2):243-52. doi: 10.1039/c5ib00225g. Epub 2016 Jan 25. PubMed PMID: 26805445.
119. Jiménez-Torres JA, Peery SL, Sung KE, Beebe DJ. LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater. 2016 Jan;5(2):198-204. doi: 10.1002/adhm.201500608. Epub 2015 Nov 26. PubMed PMID: 26610188.
120. Hong, WS, Pezzi HM, Schuster AR, Berry SM, Sung KE, Beebe DJ.  Development of a Highly Sensitive Cell-Based Assay for Detecting Botulinum Neurotoxin Type A through Neural Culture Media Optimization.J Biomol Screen. 2016 Jan;21(1):65-73. doi: 10.1177/1087057115608103. PubMed PMID: 26420788.
121. Khnouf R, Chapman B, Jin S, Beebe DJ, Fan ZH. Detection of ricin in beverages using cell-free protein synthesis in a microfluidic device.Sensors and Actuators B: Chemical. 2015; Dec; 221:723-729. doi:10.1016/j.snb.2015.06.077.
122. de Groot TE, Veserat KS, Berthier E, Beebe DJ, Theberge AB. Surface-tension driven open microfluidic platform for hanging droplet culture.Lab Chip. 2015 Dec 11. [Epub ahead of print] PubMed PMID: 26660268.
123. Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A. Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D.Biomed Microdevices. 2015 Oct;17(5):100. doi: 10.1007/s10544-015-9998-x. PubMed PMID: 26354879; PubMed Central PMCID: PMC4678772.
124. Pak C, Callander NS, Young EW, Titz B, Kim K, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S. MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells.Integr Biol (Camb). 2015 Jun 8;7(6):643-54. doi: 10.1039/c5ib00071h. Epub 2015 May 22. PubMed PMID: 25998180; PubMed Central PMCID: PMC4476551.
125. Guckenberger DJ, de Groot TE, Wan AM, Beebe DJ, Young EW. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices.Lab Chip. 2015 Jun 7;15(11):2364-78. doi: 10.1039/c5lc00234f. PubMed PMID: 25906246; PubMed Central PMCID: PMC4439323.
126. Moussavi-Harami SF, Pezzi HM, Huttenlocher A, Beebe DJ. Simple microfluidic device for studying chemotaxis in response to dual gradients.Biomed Microdevices. 2015 Jun;17(3):9955. doi: 10.1007/s10544-015-9955-8. PubMed PMID: 25893484.
127. Theberge AB, Yu J, Young EW, Ricke WA, Bushman W, Beebe DJ. Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis.Anal Chem. 2015 Mar 17;87(6):3239-46. doi: 10.1021/ac503700f. Epub 2015 Feb 26. PubMed PMID: 25719435; PubMed Central PMCID: PMC4405103.
128. Bischel LL, Beebe DJ, Sung KE. Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure. BMC Cancer. 2015. Jan 21; 15:12. doi: 10.1186/s12885-015-1007-5. PubMed PMID: 25605670; PubMed Central PMCID: PMC4305264.
129. Powers GL, Hammer KD, Domenech M, Frantskevich K, Malinowski RL, Bushman W, Beebe DJ, Marker PC. Phosphodiesterase 4D inhibitors limit prostate cancer growth potential. Molecular cancer research : MCR. 2015;13(1):149-60. Epub 2014/08/26. doi: 10.1158/1541-7786.MCR-14-0110. PubMed PMID: 25149359; 4312503
130. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2015;72(2):237-49. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
131. Sung KE, Beebe DJ. Microfluidic 3D models of cancer. Adv Drug Deliv Rev. 2014;79-80:68-78. Epub 2014/07/16. doi: 10.1016/j.addr.2014.07.002. PubMed PMID: 25017040; 4258433
132. Shelef M, Sokolove J, Lahey L, Wagner C, Sackmann E, Warner T, Wang Y, Beebe D, Robinson W, Huttenlocher A. Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor alpha-Induced Inflammatory Arthritis. Arthritis & Rheumatology. 2014;66(6):1482-91. doi: 10.1002/art.38393. PubMed PMID: WOS:000337366200010
133. Sackmann E, Fulton A, Beebe D. The present and future role of microfluidics in biomedical research. Nature. 2014;507(7491):181-9. doi: 10.1038/nature13118. PubMed PMID: WOS:000332651800029
134. Sackmann E, Berthier E, Schwantes E, Fichtinger P, Evans M, Dziadzio L, Huttenlocher A, Mathur S, Beebe D. Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(16):5813-8. doi: 10.1073/pnas.1324043111. PubMed PMID: WOS:000334694000032
135. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2014. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
136. Howard A, Pezzi H, Beebe D, Berry S. Exclusion-Based Capture and Enumeration of CD4(+) T Cells from Whole Blood for Low-Resource Settings. Jala. 2014;19(3):313-21. doi: 10.1177/2211068213509248. PubMed PMID: WOS:000336267600010
137. Guckenberger D, Thomas P, Rothbauer J, LaVanway A, Anderson M, Gilson D, Fawcett K, Berto T, Barrett K, Beebe D, Berry S. A Combined Fabrication and Instrumentation Platform for Sample Preparation. Jala. 2014;19(3):267-74. doi: 10.1177/2211068213518312. PubMed PMID: WOS:000336267600005
138. Guckenberger D, Berthier E, Young E, Beebe D. Fluorescence-Based Assessment of Plasma-Induced Hydrophilicity in Microfluidic Devices via Nile Red Adsorption and Depletion. Analytical Chemistry. 2014;86(15):7258-63. doi: 10.1021/ac501259n. PubMed PMID: WOS:000340081100018
139. Fan Z, Beebe D. Lab on a chip and circulating tumor cells. Lab on a Chip. 2014;14(1):12-3. doi: 10.1039/c3lc90125d. PubMed PMID: WOS:000327669000001
140. Casavant B, Strotman L, Tokar J, Thiede S, Traynor A, Ferguson J, Lang J, Beebe D. Paired diagnostic and pharmacodynamic analysis of rare non-small cell lung cancer cells enabled by the VerIFAST platform. Lab on a Chip. 2014;14(1):99-105. doi: 10.1039/c3lc50912e. PubMed PMID: WOS:000327669000010
141. Casavant B, Guckenberger D, Beebe D, Berry S. Efficient Sample Preparation from Complex Biological Samples Using a Sliding Lid for Immobilized Droplet Extractions. Analytical Chemistry. 2014;86(13):6355-62. doi: 10.1021/ac500574t. PubMed PMID: WOS:000338488800028
142. Carney CM, Muszynski JL, Strotman LN, Lewis SR, O’Connell RL, Beebe DJ, Theberge AB, Jorgensen JS. Cellular microenvironment dictates androgen production by murine fetal leydig cells in primary culture. Biol Reprod. 2014;91(4):85. Epub 2014/08/22. doi: 10.1095/biolreprod.114.118570. PubMed PMID: 25143354
143. Bischel LL, Sung KE, Jimenez-Torres JA, Mader B, Keely PJ, Beebe DJ. The importance of being a lumen. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014;28(11):4583-90. Epub 2014/08/01. doi: 10.1096/fj.13-243733. PubMed PMID: 25077562; 4200326
144. Bischel L, Casavant B, Young P, Eliceiri K, Basu H, Beebe D. A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells. Integrative Biology. 2014;6(6):627-35. doi: 10.1039/c3ib40240a. PubMed PMID: WOS:000336835100006
145. Berthier E, Beebe D. Gradient generation platforms: new directions for an established microfluidic technology. Lab on a Chip. 2014;14(17):3241-7. doi: 10.1039/c4lc00448e. PubMed PMID: WOS:000340204300016
146. Berry S, Singh C, Lang J, Strotman L, Alarid E, Beebe D. Streamlining gene expression analysis: integration of co-culture and mRNA purification. Integrative Biology. 2014;6(2):224-31. doi: 10.1039/c3ib40136g. PubMed PMID: WOS:000330795500011
147. Berry S, LaVanway A, Pezzi H, Guckenberger D, Anderson M, Loeb J, Beebe D. HIV Viral RNA Extraction in Wax Immiscible Filtration Assisted by Surface Tension (IFAST) Devices. Journal of Molecular Diagnostics. 2014;16(3):297-304. doi: 10.1016/j.jmoldx.2014.01.004. PubMed PMID: WOS:000335540200003
148. Berry S, Chin E, Jackson S, Strotman L, Goel M, Thompson N, Alexander C, Miyamoto S, Burgess R, Beebe D. Weak protein-protein interactions revealed by immiscible filtration assisted by surface tension. Analytical Biochemistry. 2014;447:133-40. doi: 10.1016/j.ab.2013.10.038. PubMed PMID: WOS:000330089500022
149. Young E, Berthier E, Beebe D. Assessment of Enhanced Autofluorescence and Impact on Cell Microscopy for Microfabricated Thermoplastic Devices. Analytical Chemistry. 2013;85(1):44-9. doi: 10.1021/ac3034773. PubMed PMID: WOS:000313156500010
150. Warrick J, Young E, Schmuck E, Saupe K, Beebe D. High-content adhesion assay to address limited cell samples. Integrative Biology. 2013;5(4):720-7. doi: 10.1039/c3ib20224k. PubMed PMID: WOS:000316692700009
151. Thomas P, Strotman L, Theberge A, Berthier E, O’Connell R, Loeb J, Berry S, Beebe D. Nucleic Acid Sample Preparation Using Spontaneous Biphasic Plug Flow. Analytical Chemistry. 2013;85(18):8641-6. doi: 10.1021/ac4012914. PubMed PMID: WOS:000330017400024
152. Sung K, Su X, Berthier E, Pehlke C, Friedl A, Beebe D. Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models. Plos One. 2013;8(10). doi: 10.1371/journal.pone.0076373. PubMed PMID: WOS:000325489100107
153. Su X, Theberge A, January C, Beebe D. Effect of Microculture on Cell Metabolism and Biochemistry: Do Cells Get Stressed in Microchannels? Analytical Chemistry. 2013;85(3):1562-70. doi: 10.1021/ac3027228. PubMed PMID: WOS:000314676100047
154. Strotman L, O’Connell R, Casavant B, Berry S, Sperger J, Lang J, Beebe D. Selective Nucleic Acid Removal via Exclusion (SNARE): Capturing mRNA and DNA from a Single Sample. Analytical Chemistry. 2013;85(20):9764-70. doi: 10.1021/ac402162r. PubMed PMID: WOS:000326126600049
155. Schwartz M, Rogers R, Singh S, Lee J, Loveland S, Koepsel J, Witze E, Montanez-Sauri S, Sung K, Tokuda E, Sharma Y, Everhart L, Nguyen E, Zaman M, Beebe D, Ahn N, Murphy W, Anseth K. A Quantitative Comparison of Human HT-1080 Fibrosarcoma Cells and Primary Human Dermal Fibroblasts Identifies a 3D Migration Mechanism with Properties Unique to the Transformed Phenotype. Plos One. 2013;8(12). doi: 10.1371/journal.pone.0081689. PubMed PMID: WOS:000327947800054
156. Moussavi-Harami S, Annis D, Ma W, Berry S, Coughlin E, Strotman L, Maurer L, Westphall M, Coon J, Mosher D, Beebe D. Characterization of Molecules Binding to the 70K N-Terminal Region of Fibronectin by IFAST Purification Coupled with Mass Spectrometry. Journal of Proteome Research. 2013;12(7):3393-404. doi: 10.1021/pr400225p. PubMed PMID: WOS:000321605700030
157. Montanez-Sauri S, Sung K, Berthier E, Beebe D. Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. Integrative Biology. 2013;5(3):631-40. doi: 10.1039/c3ib20225a. PubMed PMID: WOS:000315354900018
158. Lang J, Casavant B, Berry S, Strotman L, Thiede S, Sperger J, Liu G, Beebe D. Nuclear localization of the androgen receptor in prostate cancer circulating tumor cells from men who have failed androgen deprivation therapy. Journal of Clinical Oncology. 2013;31(15). PubMed PMID: WOS:000335419605265
159. Lang J, Berry S, Powers G, Beebe D, Alarid E. Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity. Integrative Biology. 2013;5(5):807-16. doi: 10.1039/c3ib20265h. PubMed PMID: WOS:000318302100006
160. Hong W, Young E, Tepp W, Johnson E, Beebe D. A Microscale Neuron and Schwann Cell Coculture Model for Increasing Detection Sensitivity of Botulinum Neurotoxin Type A. Toxicological Sciences. 2013;134(1):64-72. doi: 10.1093/toxsci/kft082. PubMed PMID: WOS:000320907900006
161. Casavant B, Mosher R, Warrick J, Maccoux L, Berry S, Becker J, Chen V, Lang J, McNeel D, Beebe D. A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells. Methods. 2013;64(2):137-43. doi: 10.1016/j.ymeth.2013.05.027. PubMed PMID: WOS:000327567400007
162. Casavant B, Guckenberger D, Berry S, Tokar J, Lang J, Beebe D. The VerIFAST: an integrated method for cell isolation and extracellular/intracellular staining. Lab on a Chip. 2013;13(3):391-6. doi: 10.1039/c2lc41136a. PubMed PMID: WOS:000312947300010
163. Casavant B, Berthier E, Theberge A, Berthier J, Montanez-Sauri S, Bischel L, Brakke K, Hedman C, Bushman W, Keller N, Beebe D. Suspended microfluidics. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(25):10111-6. doi: 10.1073/pnas.1302566110. PubMed PMID: WOS:000321500200030
164. Bischel L, Young E, Mader B, Beebe D. Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. Biomaterials. 2013;34(5):1471-7. doi: 10.1016/j.biomaterials.2012.11.005. PubMed PMID: WOS:000313929400003
165. Bischel L, Mader B, Green J, Huttenlocher A, Beebe D. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab on a Chip. 2013;13(9):1732-6. doi: 10.1039/c3lc50099c. PubMed PMID: WOS:000316962700009
166. Berthier E, Lim F, Deng Q, Guo C, Kontoyiannis D, Wang C, Rindy J, Beebe D, Huttenlocher A, Keller N. Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites. Plos Pathogens. 2013;9(4). doi: 10.1371/journal.ppat.1003289. PubMed PMID: WOS:000318072700030
167. Berthier E, Guckenberger D, Cavnar P, Huttenlocher A, Keller N, Beebe D. Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab on a Chip. 2013;13(3):424-31. doi: 10.1039/c2lc41019b. PubMed PMID: WOS:000312947300014
168. Berry S, Regehr K, Casavant B, Beebe D. Automated Operation of Immiscible Filtration Assisted by Surface Tension (IFAST) Arrays for Streamlined Analyte Isolation. Jala. 2013;18(3):206-11. doi: 10.1177/2211068212462023. PubMed PMID: WOS:000325923700003
169. Beebe D, Ingber D, den Toonder J. Organs on Chips 2013. Lab on a Chip. 2013;13(18):3447-8. doi: 10.1039/c3lc90080k. PubMed PMID: WOS:000323111300001
170. Young E, Pak C, Kahl B, Yang D, Callander N, Miyamoto S, Beebe D. e-Blood Microscale functional cytomics for studying hematologic cancers. Blood. 2012;119(10):E76-E85. doi: 10.1182/blood-2011-10-384347. PubMed PMID: WOS:000301356000002
171. Su G, Sung K, Beebe D, Friedl A. Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts. Plos One. 2012;7(10). doi: 10.1371/journal.pone.0046685. PubMed PMID: WOS:000309831500057
172. Strotman L, Lin G, Berry S, Johnson E, Beebe D. Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension). Analyst. 2012;137(17):4023-8. doi: 10.1039/c2an35506j. PubMed PMID: WOS:000306932400022
173. Sackmann E, Berthier E, Young E, Shelef M, Wernimont S, Huttenlocher A, Beebe D. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012;120(14):E45-E53. doi: 10.1182/blood-2012-03-416453. PubMed PMID: WOS:000311616900001
174. Resto P, Berthier E, Beebe D, Williams J. An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices. Lab on a Chip. 2012;12(12):2221-8. doi: 10.1039/c2lc20858j. PubMed PMID: WOS:000304448700015
175. Lee J, Kim Y, Beebe D, Kim B. Harnessing gravitational, hydrodynamic and negative dielectrophoretic forces for higher throughput cell sorting. Biochip Journal. 2012;6(3):229-39. doi: 10.1007/s13206-012-6305-2. PubMed PMID: WOS:000308779800005
176. Lee A, Beebe D, Palecek S. Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels. Biomedical Microdevices. 2012;14(2):247-57. doi: 10.1007/s10544-011-9602-y. PubMed PMID: WOS:000301544500001
177. Lang J, Casavant B, Beebe D. Circulating Tumor Cells: Getting More from Less. Science Translational Medicine. 2012;4(141). doi: 10.1126/scitranslmed.3004261. PubMed PMID: WOS:000306108800002
178. Guckenberger D, Berthier E, Young E, Beebe D. Induced hydrophobic recovery of oxygen plasma-treated surfaces. Lab on a Chip. 2012;12(13):2317-21. doi: 10.1039/c2lc21052e. PubMed PMID: WOS:000305288600006
179. Goel S, Chin E, Fakhraldeen S, Berry S, Beebe D, Alexander C. Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts. Journal of Biological Chemistry. 2012;287(20):16454-66. doi: 10.1074/jbc.M112.362137. PubMed PMID: WOS:000304030900036
180. Domenech M, Bjerregaard R, Bushman W, Beebe D. Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integrative Biology. 2012;4(2):142-52. doi: 10.1039/c1ib00104c. PubMed PMID: WOS:000299640700003
181. Cavnar P, Mogen K, Berthier E, Beebe D, Huttenlocher A. The Actin Regulatory Protein HS1 Interacts with Arp2/3 and Mediates Efficient Neutrophil Chemotaxis. Journal of Biological Chemistry. 2012;287(30):25466-77. doi: 10.1074/jbc.M112.364562. PubMed PMID: WOS:000306651700053
182. Casavant B, Tokar J, Lang J, Abel E, Beebe D. Isolation of renal cell carcinoma cells from blood samples using the vertical immiscible filtration assisted by surface tension (VerIFAST) microfluidic platform. Bju International. 2012;110:3-. PubMed PMID: WOS:000308932400007
183. Bischel L, Lee S, Beebe D. A Practical Method for Patterning Lumens through ECM Hydrogels via Viscous Finger Patterning. Jala. 2012;17(2):96-103. doi: 10.1177/2211068211426694. PubMed PMID: WOS:000304775300002
184. Berry S, Maccoux L, Beebe D. Streamlining Immunoassays with Immiscible Filtrations Assisted by Surface Tension. Analytical Chemistry. 2012;84(13):5518-23. doi: 10.1021/ac300085m. PubMed PMID: WOS:000305871300012
185. Young E, Berthier E, Guckenberger D, Sackmann E, Lamers C, Meyvantsson I, Huttenocher A, Beebe D. Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays. Analytical Chemistry. 2011;83(4):1408-17. doi: 10.1021/ac102897h. PubMed PMID: WOS:000287176900037
186. Sung K, Yang N, Pehlke C, Keely P, Eliceiri K, Friedl A, Beebe D. Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integrative Biology. 2011;3(4):439-50. doi: 10.1039/c0ib00063a. PubMed PMID: WOS:000289154600016
187. Su X, Young E, Underkofler H, Kamp T, January C, Beebe D. Microfluidic Cell Culture and Its Application in High-Throughput Drug Screening: Cardiotoxicity Assay for hERG Channels. Journal of Biomolecular Screening. 2011;16(1):101-11. doi: 10.1177/1087057110386218. PubMed PMID: WOS:000286063300011
188. Montanez-Sauri S, Sung K, Puccinelli J, Pehlke C, Beebe D. Automation of Three-Dimensional Cell Culture in Arrayed Microfluidic Devices. Jala. 2011;16(3):171-85. doi: 10.1016/j.jala.2011.02.003. PubMed PMID: WOS:000290826000002
189. Kshitiz, Kim D, Beebe D, Levchenko A. Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends in Biotechnology. 2011;29(8):399-408. doi: 10.1016/j.tibtech.2011.03.006. PubMed PMID: WOS:000293485300005
190. Frisk M, Lin G, Johnson E, Beebe D. Synaptotagmin II peptide-bead conjugate for botulinum toxin enrichment and detection in microchannels. Biosensors & Bioelectronics. 2011;26(5):1929-35. doi: 10.1016/j.bios.2010.06.035. PubMed PMID: WOS:000286904400022
191. Cavnar P, Berthier E, Beebe D, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. Journal of Cell Biology. 2011;193(3):465-73. doi: 10.1083/jcb.201010143. PubMed PMID: WOS:000290676400007
192. Berthier E, Warrick J, Casavant B, Beebe D. Pipette-friendly laminar flow patterning for cell-based assays. Lab on a Chip. 2011;11(12):2060-5. doi: 10.1039/c0lc00539h. PubMed PMID: WOS:000291166000015
193. Berry S, Strotman L, Kueck J, Alarid E, Beebe D. Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomedical Microdevices. 2011;13(6):1033-42. doi: 10.1007/s10544-011-9573-z. PubMed PMID: WOS:000297121700009
194. Berry S, Alarid E, Beebe D. One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST). Lab on a Chip. 2011;11(10):1747-53. doi: 10.1039/c1lc00004g. PubMed PMID: WOS:000289951200006
195. Young E, Beebe D. Fundamentals of microfluidic cell culture in controlled microenvironments. Chemical Society Reviews. 2010;39(3):1036-48. doi: 10.1039/b909900j. PubMed PMID: WOS:000274920300012
196. Puccinelli J, Su X, Beebe D. Automated High-Throughput Microchannel Assays for Cell Biology: Operational Optimization and Characterization. Jala. 2010;15(1):25-32. doi: 10.1016/j.jala.2009.10.002. PubMed PMID: WOS:000295434000004
197. Paguirigan A, Puccinelli J, Su X, Beebe D. Expanding the Available Assays: Adapting and Validating In-Cell Westerns in Microfluidic Devices for Cell-Based Assays. Assay and Drug Development Technologies. 2010;8(5):591-601. doi: 10.1089/adt.2010.0274. PubMed PMID: WOS:000283438400006
198. Lopez-Garcia M, Beebe D, Crone W. Mechanical Interactions of Mouse Mammary Gland Cells with Collagen in a Three-Dimensional Construct. Annals of Biomedical Engineering. 2010;38(8):2485-98. doi: 10.1007/s10439-010-0015-5. PubMed PMID: WOS:000279682000002
199. Lopez-Garcia M, Beebe D, Crone W. Young’s modulus of collagen at slow displacement rates. Bio-Medical Materials and Engineering. 2010;20(6):361-9. doi: 10.3233/bme-2010-0649. PubMed PMID: WOS:000286596200006
200. Lee A, Arena C, Beebe D, Palecek S. Macroporous hydrogels for quantifying cancer-inducing kinase activity in microfluidic devices. Abstracts of Papers of the American Chemical Society. 2010;239. PubMed PMID: WOS:000208189300681
201. Lee A, Arena C, Beebe D, Palecek S. Development of Macroporous Poly(ethylene glycol) Hydrogel Arrays within Microfluidic Channels. Biomacromolecules. 2010;11(12):3316-24. doi: 10.1021/bm100792y. PubMed PMID: WOS:000285267500012
202. Ju J, Warrick J, Beebe D. A Cell Programmable Assay (CPA) chip. Lab on a Chip. 2010;10(16):2071-6. doi: 10.1039/c005103a. PubMed PMID: WOS:000280394800008
203. doi: 10.1111/j.1474-9726.2010.00600.x. PubMed PMID: WOS:000281897400004
204. Beebe D, Huttenlocher A. Introduction to the Mechanisms of Directed Cell Migration themed issue. Integrative Biology. 2010;2(11-12):559-60. doi: 10.1039/c0ib90017f. PubMed PMID: WOS:000283741400001
205. Bauer M, Su G, Beebe D, Friedl A. 3D microchannel co-culture: method and biological validation. Integrative Biology. 2010;2(7-8):371-8. doi: 10.1039/c0ib00001a. PubMed PMID: WOS:000280769200006
206. Zhu Y, Warrick J, Haubert K, Beebe D, Yin J. Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomedical Microdevices. 2009;11(3):565-70. doi: 10.1007/s10544-008-9263-7. PubMed PMID: WOS:000265440300005
207. Sung K, Su G, Pehlke C, Trier S, Eliceiri K, Keely P, Friedl A, Beebe D. Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials. 2009;30(27):4833-41. doi: 10.1016/j.biomaterials.2009.05.043. PubMed PMID: WOS:000269330400045
208. Regehr K, Domenech M, Koepsel J, Carver K, Ellison-Zelski S, Murphy W, Schuler L, Alarid E, Beebe D. Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab on a Chip. 2009;9(15):2132-9. doi: 10.1039/b903043c. PubMed PMID: WOS:000268033900003
209. Paguirigan A, Beebe D. From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integrative Biology. 2009;1(2):182-95. doi: 10.1039/b814565b. PubMed PMID: WOS:000267113600005
210. Mohanty S, Warrick J, Gorski J, Beebe D. An accessible micro-capillary electrophoresis device using surface-tension-driven flow. Electrophoresis. 2009;30(9):1470-81. doi: 10.1002/elps.200800595. PubMed PMID: WOS:000266312800006
211. Kim D, Lokuta M, Huttenlocher A, Beebe D. Selective and tunable gradient device for cell culture and chemotaxis study. Lab on a Chip. 2009;9(12):1797-800. doi: 10.1039/b901613a. PubMed PMID: WOS:000266616000021
212. Khnouf R, Beebe D, Fan Z. Cell-free protein expression in a microchannel array with passive pumping. Lab on a Chip. 2009;9(1):56-61. doi: 10.1039/b808034h. PubMed PMID: WOS:000262649400009
213. Frisk M, Tepp W, Johnson E, Beebe D. Self-Assembled Peptide Monolayers as a Toxin Sensing Mechanism within Arrayed Microchannels. Analytical Chemistry. 2009;81(7):2760-7. doi: 10.1021/ac802707u. PubMed PMID: WOS:000264759400046
214. Domenech M, Yu H, Warrick J, Badders N, Meyvantsson I, Alexander C, Beebe D. Cellular observations enabled by microculture: paracrine signaling and population demographics. Integrative Biology. 2009;1(3):267-74. doi: 10.1039/b823059e. PubMed PMID: WOS:000267113900005
215. Beebe D, Barcellos-Hoff M. The development of integrative biology: bridging the gap-a view from the Scientific Editors. Integrative Biology. 2009;1(2):145-7. doi: 10.1039/b822329g. PubMed PMID: WOS:000267113600001
216. Paguirigan A, Beebe D. Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. Bioessays. 2008;30(9):811-21. doi: 10.1002/bies.20804. PubMed PMID: WOS:000258891400005
217. Meyvantsson I, Warrick J, Hayes S, Skoien A, Beebe D. Automated cell culture in high density tubeless microfluidic device arrays. Lab on a Chip. 2008;8(5):717-24. doi: 10.1039/b715375a. PubMed PMID: WOS:000255276700012
218. Meyvantsson I, Beebe D. Cell Culture Models in Microfluidic Systems. Annual Review of Analytical Chemistry. 2008;1:423-49. doi: 10.1146/annurev.anchem.1.031207.113042. PubMed PMID: WOS:000262525200014
219. Lopez-Garcia M, Monson R, Haubert K, Wheeler M, Beebe D. Sperm motion in a microfluidic fertilization device. Biomedical Microdevices. 2008;10(5):709-18. doi: 10.1007/s10544-008-9182-7. PubMed PMID: WOS:000258581700012
220. Kwon G, Park J, Kim J, Frisk M, Beebe D, Lee S. Biomimetic Soft Multifunctional Miniature Aquabots. Small. 2008;4(12):2148-53. doi: 10.1002/smll.200800315. PubMed PMID: WOS:000261905100012
221. Kim D, Beebe D. Interfacial formation of porous membranes with poly(ethylene glycol) in a microfluidic environment. Journal of Applied Polymer Science. 2008;110(3):1581-9. doi: 10.1002/app.27890. PubMed PMID: WOS:000259168100038
222. Ju J, Park J, Kim K, Kim H, Berthier E, Beebe D, Lee S. Backward flow in a surface tension driven micropump. Journal of Micromechanics and Microengineering. 2008;18(8). doi: 10.1088/0960-1317/18/8/087002. PubMed PMID: WOS:000257891600023
223. Jongpaiboonkit L, King W, Lyons G, Paguirigan A, Warrick J, Beebe D, Murphy W. An adaptable hydrogel array format for 3-dimensional cell culture and analysis. Biomaterials. 2008;29(23):3346-56. doi: 10.1016/j.biomaterials.2008.04.040. PubMed PMID: WOS:000257344600007
224. Frisk M, Berthier E, Tepp W, Johnson E, Beebe D. Bead-based microfluidic toxin sensor integrating evaporative signal amplification. Lab on a Chip. 2008;8(11):1793-800. doi: 10.1039/b811075a. PubMed PMID: WOS:000261686100010
225. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays – Part 2. Characterization of convection and diffusion for cell biology. Lab on a Chip. 2008;8(6):860-4. doi: 10.1039/b717423c. PubMed PMID: WOS:000256115200002
226. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays – Part 1. Volume loss in high throughput assays. Lab on a Chip. 2008;8(6):852-9. doi: 10.1039/b717422e. PubMed PMID: WOS:000256115200001
227. Badders N, Yu H, Alexander C, Beebe D. Quantification of small cell numbers with a microchannel device. Biotechniques. 2008;45(3):321-+. doi: 10.2144/000112906. PubMed PMID: WOS:000263638100023
228. Abhyankar V, Toepke M, Cortesio C, Lokuta M, Huttenlocher A, Beebe D. A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab on a Chip. 2008;8(9):1507-15. doi: 10.1039/b803533d. PubMed PMID: WOS:000259676000013
229. Zheng T, Yu H, Alexander C, Beebe D, Smith L. Lectin-modified microchannels for mammalian cell capture and purification. Biomedical Microdevices. 2007;9(4):611-7. doi: 10.1007/s10544-007-9074-2. PubMed PMID: WOS:000248007500020
230. Yu H, Alexander C, Beebe D. Understanding microchannel culture: parameters involved in soluble factor signaling. Lab on a Chip. 2007;7(6):726-30. doi: 10.1039/b618793e. PubMed PMID: WOS:000247566400020
231. Yu H, Alexander C, Beebe D. A plate reader-compatible microchannel array for cell biology assays. Lab on a Chip. 2007;7(3):388-91. doi: 10.1039/b612358a. PubMed PMID: WOS:000244616900014
232. Wheeler M, Walters E, Beebe D. Toward culture of single gametes: The development of microfluidic platforms for assisted reproduction. Theriogenology. 2007;68:S178-S89. doi: 10.1016/j.theriogenology.2007.04.042|10.1016/i.theriogenology.2007.04.042. PubMed PMID: WOS:000248916700023
233. Warrick J, Meyvantsson I, Ju J, Beebe D. High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab on a Chip. 2007;7(3):316-21. doi: 10.1039/b613350a. PubMed PMID: WOS:000244616900004
234. Toepke M, Abhyankar V, Beebe D. Microfluidic logic gates and timers. Lab on a Chip. 2007;7(11):1449-53. doi: 10.1039/b708764k. PubMed PMID: WOS:000250428200016
235. Paguirigan A, Beebe D, Alexander C. Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity. Cell Proliferation. 2007;40(1):106-24. PubMed PMID: WOS:000243442600009
236. Paguirigan A, Beebe D. Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nature Protocols. 2007;2(7):1782-8. doi: 10.1038/nprot.2007.256. PubMed PMID: WOS:000253139200024
237. Lopez-Garcia M, Beebe D, Crone W. Characterization of poly(isobornyl acrylate) as a construction material for microfluidic applications. Journal of Applied Polymer Science. 2007;105(4):1894-902. doi: 10.1002/app.26195. PubMed PMID: WOS:000247576600022
238. Kim D, Beebe D. Hydrogel-based reconfigurable components for microfluidic devices. Lab on a Chip. 2007;7(2):193-8. doi: 10.1039/b612995a. PubMed PMID: WOS:000244616300007
239. Kim D, Beebe D. A bi-polymer micro one-way valve. Sensors and Actuators a-Physical. 2007;136(1):426-33. doi: 10.1016/j.sna.2006.11.004. PubMed PMID: WOS:000246463000057
240. Frisk M, Tepp W, Lin G, Johnson E, Beebe D. Substrate-modified hydrogels for autonomous sensing of botulinum neurotoxin type A. Chemistry of Materials. 2007;19(24):5842-4. doi: 10.1021/cm7021032. PubMed PMID: WOS:000251150900014
241. Dong L, Agarwal A, Beebe D, Jiang H. Variable-focus liquid microlenses and microlens arrays actuated by thermoresponsive hydrogels. Advanced Materials. 2007;19(3):401-+. doi: 10.1002/adma.200601561. PubMed PMID: WOS:000244217800013
242. Berthier E, Beebe D. Flow rate analysis of a surface tension driven passive micropump. Lab on a Chip. 2007;7(11):1475-8. doi: 10.1039/b707637a. PubMed PMID: WOS:000250428200020
243. Agarwal A, Dong L, Beebe D, Jiang H. Autonomously-triggered microfluidic cooling using thermo-responsive hydrogels. Lab on a Chip. 2007;7(3):310-5. doi: 10.1039/b617767k. PubMed PMID: WOS:000244616900003
244. Agarwal A, Atencia J, Beebe D, Jiang H. Design of microfluidic impellers capable of bi-directional pumping under a single rotating magnetic actuation. Proceedings of the Ieee Twentieth Annual International Conference on Micro Electro Mechanical Systems, Vols 1 and 2. 2007:502-5. PubMed PMID: WOS:000255867800126
245. Abhyankar V, Beebe D. Spatiotemporal micropatterning of cells on arbitrary substrates. Analytical Chemistry. 2007;79(11):4066-73. doi: 10.1021/ac062371p. PubMed PMID: WOS:000246842100011
246. Wheeler M, Rutledge J, Fischer-Brown A, VanEtten T, Malusky S, Beebe D. Application of sexed semen technology to in vitro embryo production in cattle. Theriogenology. 2006;65(1):219-27. doi: 10.1016/j.theriogenology.2005.09.032. PubMed PMID: WOS:000234013900020
247. Toepke M, Beebe D. PDMS absorption of small molecules and consequences in microfluidic applications. Lab on a Chip. 2006;6(12):1484-6. doi: 10.1039/b612140c. PubMed PMID: WOS:000243212600009
248. Tang H, Beebe D. An oral tactile interface for blind navigation. Ieee Transactions on Neural Systems and Rehabilitation Engineering. 2006;14(1):116-23. doi: 10.1109/tnsre.2005.862696|10.1109/tnsre.2005.86296. PubMed PMID: WOS:000236519000015
249. Sridharamurthy S, Agarwal A, Beebe D, Jiang H. Dissolvable membranes as sensing elements for microfluidics based biological/chemical sensors. Lab on a Chip. 2006;6(7):840-2. doi: 10.1039/b607066c. PubMed PMID: WOS:000238580900002
250. Park J, Teren S, Tepp W, Beebe D, Johnson E, Abbott N. Formation of oligopeptide-based polymeric membranes at interfaces between aqueous phases and thermotropic liquid crystals. Chemistry of Materials. 2006;18(26):6147-51. doi: 10.1021/cm0606732. PubMed PMID: WOS:000242935500015
251. Paguirigan A, Beebe D, Liu B, Alexander C. Mammary stem and progenitor cells: Tumour precursors? European Journal of Cancer. 2006;42(9):1225-36. doi: 10.1016/j.ejca.2006.01.048. PubMed PMID: WOS:000238559700006
252. Mohanty S, Kim D, Beebe D. Do-it-yourself microelectrophoresis chips with integrated sample recovery. Electrophoresis. 2006;27(19):3772-8. doi: 10.1002/elps.200600238. PubMed PMID: WOS:000241621000010
253. Kim D, Chesler N, Beebe D. A method for dynamic system characterization using hydraulic series resistance. Lab on a Chip. 2006;6(5):639-44. doi: 10.1039/b517054k. PubMed PMID: WOS:000237229200006
254. Kim D, Beebe D. A sensing method based on elastic instabilities of swelling hydrogels. 2006 International Conference on Microtechnologies in Medicine and Biology. 2006:292-4. doi: 10.1109/mmb.2006.251553. PubMed PMID: WOS:000244177200087
255. Kaczmarek K, Nammi K, Agarwal A, Tyler M, Haase S, Beebe D. Polarity effect in electrovibration for tactile display. Ieee Transactions on Biomedical Engineering. 2006;53(10):2047-54. doi: 10.1109/tbme.2006.881804. PubMed PMID: WOS:000240698800021
256. Eddington D, Puccinelli J, Beebe D. Thermal aging and reduced hydrophobic recovery of polydimethylsiloxane. Sensors and Actuators B-Chemical. 2006;114(1):170-2. doi: 10.1016/j.snb.2005.04.037. PubMed PMID: WOS:000236009300023
257. Dong L, Agarwal A, Beebe D, Jiang H. Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature. 2006;442(7102):551-4. doi: 10.1038/nature05024. PubMed PMID: WOS:000239455900040
258. Atencia J, Beebe D. Steady flow generation in microcirculatory systems. Lab on a Chip. 2006;6(4):567-74. doi: 10.1039/b514070f. PubMed PMID: WOS:000236386500015
259. Agarwal A, Beebe D, Jiang H. Integration of polymer and metal microstructures using liquid-phase photopolymerization. Journal of Micromechanics and Microengineering. 2006;16(2):332-40. doi: 10.1088/0960-1317/16/2/018. PubMed PMID: WOS:000235674000018
260. Abhyankar V, Lokuta M, Huttenlocher A, Beebe D. Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab on a Chip. 2006;6(3):389-93. doi: 10.1039/b514133h. PubMed PMID: WOS:000235993800008
261. Zeringue H, Wheeler M, Beebe D. A microfluidic method for removal of the zona pellucida from mammalian embryos. Lab on a Chip. 2005;5(1):108-10. doi: 10.1039/b406703g. PubMed PMID: WOS:000225889000016
262. Zeringue H, Rutledge J, Beebe D. Early mammalian embryo development depends on cumulus removal technique. Lab on a Chip. 2005;5(1):86-90. doi: 10.1039/b316494m. PubMed PMID: WOS:000225889000012
263. Yu H, Shkel I, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Effect of microchannel geometry on cell proliferation: Experiments and interpretation. Micro Total Analysis Systems 2004, Vol 1. 2005(296):602-4. PubMed PMID: WOS:000228997000202
264. Yu H, Meyvantsson I, Shkel I, Beebe D. Diffusion dependent cell behavior in microenvironments. Lab on a Chip. 2005;5(10):1089-95. doi: 10.1039/b504403k. PubMed PMID: WOS:000232003200013
265. Sridharamurthy S, Agarwal A, Beebe D, Jiang H, IEEE. A fluidic chemical and biological sensing mechanism with high transduction based on dissolvable membranes. Transducers ’05, Digest of Technical Papers, Vols 1 and 2. 2005:1820-3. PubMed PMID: WOS:000232189100450
266. Sershen S, Mensing G, Ng M, Halas N, Beebe D, West J. Independent optical control of microfluidic valves formed from optomechanically responsive nanocomposite hydrogels. Advanced Materials. 2005;17(11):1366-+. doi: 10.1002/adma.200401239. PubMed PMID: WOS:000229718400007
267. Moorthy J, Bergendahl V, Burgess R, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D. Hydrogel based environments for biomolecular interaction studies. Micro Total Analysis Systems 2004, Vol 2. 2005(297):240-2. PubMed PMID: WOS:000229017400079
268. Meyvantsson I, Beebe D, IEEE. High throughput microfluidic system for heterogeneous assays. 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005:42-4. doi: 10.1109/mmb.2005.1548379. PubMed PMID: WOS:000234204800016
269. Kim D, Tyler M, Beebe D. Development of a tongue-operated switch array as an alternative input device. International Journal of Human-Computer Interaction. 2005;18(1):19-38. doi: 10.1207/s15327590ijhc1801_2. PubMed PMID: WOS:000227751300002
270. Kim D, Mohanty S, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Active assembly methods for microfluidic systems. Micro Total Analysis Systems 2004, Vol 1. 2005(296):36-8. PubMed PMID: WOS:000228997000012
271. Jeong W, Kim J, Choo J, Lee E, Han C, Beebe D, Seong G, Lee S. Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems. Langmuir. 2005;21(9):3738-41. doi: 10.1021/la050105l|10.1021/la0501051. PubMed PMID: WOS:000228590800004
272. Eddington D, Beebe D. Development of a disposable infusion system for the delivery of protein therapeutics. Biomedical Microdevices. 2005;7(3):223-30. doi: 10.1007/s10544-005-3029-2. PubMed PMID: WOS:000231245400008
273. Clark S, Haubert K, Beebe D, Ferguson C, Wheeler M. Reduction of polyspermic penetration using biomimetic microfluidic technology during in vitro fertilization. Lab on a Chip. 2005;5(11):1229-32. doi: 10.1039/b504397m. PubMed PMID: WOS:000232774900004
274. Bassetti M, Chatterjee A, Aluru N, Beebe D. Development and modeling of electrically triggered hydrogels for microfluidic applications. Journal of Microelectromechanical Systems. 2005;14(5):1198-207. doi: 10.1109/jmems.2005.845407. PubMed PMID: WOS:000232571000033
275. Atencia J, Yu H, Beebe D, Laurell T, Nilsson J, Jensen K, Harrison D, Kutter J. Micropump for recirculation of insect cells in suspension. Micro Total Analysis Systems 2004, Vol 1. 2005(296):605-7. PubMed PMID: WOS:000228997000203
276. Atencia J, Beebe D. Controlled microfluidic interfaces. Nature. 2005;437(7059):648-55. doi: 10.1038/nature04163. PubMed PMID: WOS:000232157900038
277. Agarwal A, Sridharamurthy S, Beebe D, Jiang H, IEEE. An on-chip autonomous microfluidic cooling system. Transducers ’05, Digest of Technical Papers, Vols 1 and 2. 2005:364-7. PubMed PMID: WOS:000232189100088
278. Agarwal A, Sridharamurthy S, Beebe D, Jiang H. Programmable autonomous micromixers and micropumps. Journal of Microelectromechanical Systems. 2005;14(6):1409-21. doi: 10.1109/jmems.2005.859101. PubMed PMID: WOS:000233953000020
279. Wheeler M, Clark S, Beebe D. Developments in in vitro technologies for swine embryo production. Reproduction Fertility and Development. 2004;16(1-2):15-25. doi: 10.1071/rd03074. PubMed PMID: WOS:000187526900003
280. Walker G, Zeringue H, Beebe D. Microenvironment design considerations for cellular scale studies. Lab on a Chip. 2004;4(2):91-7. doi: 10.1039/b311214d. PubMed PMID: WOS:000221029900005
281. Walker G, Ozers M, Beebe D. Cell infection within a microfluidic device using virus gradients. Sensors and Actuators B-Chemical. 2004;98(2-3):347-55. doi: 10.1016/j.snb.2003.10.014. PubMed PMID: WOS:000220214300032
282. Raty S, Walters E, Davis J, Zeringue H, Beebe D, Rodriguez-Zas S, Wheeler M. Embryonic development in the mouse is enhanced via microchannel culture. Lab on a Chip. 2004;4(3):186-90. doi: 10.1039/b316437c. PubMed PMID: WOS:000221708800008
283. Moorthy J, Mensing G, Kim D, Mohanty S, Eddington D, Tepp W, Johnson E, Beebe D. Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis. 2004;25(10-11):1705-13. doi: 10.1002/elps.200405888. PubMed PMID: WOS:000222140400037
284. Mohanty S, Sohn L, Beebe D, ieee. Hybrid polymer/thin film impedance system for label free monitoring of. Proceedings of the 26th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-7. 2004;26:2561-4. PubMed PMID: WOS:000225461800662
285. Mensing G, Pearce T, Graham M, Beebe D. An externally driven magnetic microstirrer. Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences. 2004;362(1818):1059-68. doi: 10.1098/rsta.2003.1362. PubMed PMID: WOS:000221263000008
286. Johnson B, Beebe D, Crone W. Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices. Materials Science & Engineering C-Biomimetic and Supramolecular Systems. 2004;24(4):575-81. doi: 10.1016/j.msec.2003.11.002. PubMed PMID: WOS:000221992700019
287. Johnson B, Bauer J, Niedermaier D, Crone W, Beebe D. Experimental techniques for mechanical characterization of hydrogels at the microscale. Experimental Mechanics. 2004;44(1):21-8. doi: 10.1007/bf02427971|10.1177/0014485104039629. PubMed PMID: WOS:000188607100003
288. Jeong W, Kim J, Kim S, Lee S, Mensing G, Beebe D. Hydrodynamic microfabrication via “on the fly” photopolymerization of microscale fibers and tubes. Lab on a Chip. 2004;4(6):576-80. doi: 10.1039/b411249k. PubMed PMID: WOS:000225382800009
289. Eddington D, Beebe D. Flow control with hydrogels. Advanced Drug Delivery Reviews. 2004;56(2):199-210. doi: 10.1016/j.addr.2003.08.013. PubMed PMID: WOS:000188777900006
290. Eddington D, Beebe D. A valved responsive hydrogel microdispensing device with integrated pressure source. Journal of Microelectromechanical Systems. 2004;13(4):586-93. doi: 10.1109/jmems.2004.832190. PubMed PMID: WOS:000223180200005
291. Bauer J, Saif T, Beebe D. Surface tension driven formation of microstructures. Journal of Microelectromechanical Systems. 2004;13(4):553-8. doi: 10.1109/jmems.2004.832181. PubMed PMID: WOS:000223180200001
292. Atencia J, Beebe D. Magnetically-driven biomimetic micro pumping using vortices. Lab on a Chip. 2004;4(6):598-602. doi: 10.1039/b407710e. PubMed PMID: WOS:000225382800012
293. Vijayendran R, Motsegood K, Beebe D, Leckband D. Evaluation of a three-dimensional micromixer in a surface-based biosensor. Langmuir. 2003;19(5):1824-8. doi: 10.1021/la0262250. PubMed PMID: WOS:000181309600050
294. Tang H, Beebe D. Design and microfabrication of a flexible oral electrotactile display. Journal of Microelectromechanical Systems. 2003;12(1):29-36. doi: 10.1109/jmems.2002.807478. PubMed PMID: WOS:000181346200004
295. Moorthy J, Beebe D. Organic and biomimetic designs for microfluidic systems – New strategies offer a flexible approach to designing microscale devices. Analytical Chemistry. 2003;75(13):292A-301A. doi: 10.1021/ac0313567. PubMed PMID: WOS:000183975300003
296. Moorthy J, Beebe D. In situ fabricated porous filters for microsystems. Lab on a Chip. 2003;3(2):62-6. doi: 10.1039/b300450c. PubMed PMID: WOS:000182988000006
297. Lee S, Jeong W, Beebe D. Microfluidic valve with cored glass microneedle for microinjection. Lab on a Chip. 2003;3(3):164-7. doi: 10.1039/b305692a. PubMed PMID: WOS:000184541100007
298. Lee S, Eddington D, Kim Y, Kim W, Beebe D. Control mechanism of an organic self-regulating microfluidic system. Journal of Microelectromechanical Systems. 2003;12(6):848-54. doi: 10.1109/jmems.2003.820292. PubMed PMID: WOS:000187936400010
299. Khoury C, Adalsteinsson T, Johnson B, Crone W, Beebe D. Tunable microfabricated hydrogels – A study in protein interaction and diffusion. Biomedical Microdevices. 2003;5(1):35-45. doi: 10.1023/a:1024411332492. PubMed PMID: WOS:000183771900005
300. Clark S, Walters E, Beebe D, Wheeler M. Determination of the BSA content needed for culture of porcine embryos fertilized in microchannels. Biology of Reproduction. 2003;68:250-. PubMed PMID: WOS:000183821400390
301. Zhao B, Viernes N, Moore J, Beebe D. Control and applications of immiscible liquids in microchannels. Journal of the American Chemical Society. 2002;124(19):5284-5. doi: 10.1021/ja025835j. PubMed PMID: WOS:000175521200016
302. Zhao B, Moore J, Beebe D. Principles of surface-directed liquid flow in microfluidic channels. Analytical Chemistry. 2002;74(16):4259-68. doi: 10.1021/ac020269w. PubMed PMID: WOS:000177502700043
303. Wang L, Beebe D. Characterization of a silicon-based shear-force sensor on human subjects. Ieee Transactions on Biomedical Engineering. 2002;49(11):1340-7. doi: 10.1109/tbme.2002.804586. PubMed PMID: WOS:000179177000012
304. Walker G, Ozers M, Beebe D. Insect cell culture in microfluidic channels. Biomedical Microdevices. 2002;4(3):161-6. doi: 10.1023/a:1016088128057. PubMed PMID: WOS:000177776600001
305. Walker G, Beebe D, Dittmar A, Beebe D. Evaporation-driven microfluidic sample concentration. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:523-6. doi: 10.1109/mmb.2002.1002397. PubMed PMID: WOS:000176123400109
306. Walker G, Beebe D. An evaporation-based microfluidic sample concentration method. Lab on a Chip. 2002;2(2):57-61. doi: 10.1039/b202473j. PubMed PMID: WOS:000178030700004
307. Walker G, Beebe D. A passive pumping method for microfluidic devices. Lab on a Chip. 2002;2(3):131-4. doi: 10.1039/b204381e. PubMed PMID: WOS:000178030900003
308. Quirk D, Beebe D, IEEE. Rapid photolithographic fabrication of three dimensional microfluidic devices. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:1820-1. doi: 10.1109/iembs.2002.1053043. PubMed PMID: WOS:000180194800897
309. Moorthy J, Beebe D, Dittmar A, Beebe D. In situ fabricated porous filter – Characterization and biological applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:514-7. doi: 10.1109/mmb.2002.1002394. PubMed PMID: WOS:000176123400107
310. Moorthy J, Beebe D. A hydrogel readout for autonomous detection of ions in microchannels. Lab on a Chip. 2002;2(2):76-80. doi: 10.1039/b110094g. PubMed PMID: WOS:000178030700008
311. Mensing G, Pearce T, Beebe D, Dittmar A, Beebe D. An in-plane active magnetic mixer for microfluidic applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:531-4. doi: 10.1109/mmb.2002.1002400. PubMed PMID: WOS:000176123400111
312. Liu R, Yu Q, Beebe D. Fabrication and characterization of hydrogel-based microvalves. Journal of Microelectromechanical Systems. 2002;11(1):45-53. doi: 10.1109/84.982862. PubMed PMID: WOS:000173751000006
313. Kim D, Agarwal A, Delisle M, Tyler M, Beebe D, IEEE. Geometric optimization of a tongue-operated switch array. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:2441-2. PubMed PMID: WOS:000180194801197
314. Khoury C, Mensing G, Beebe D. Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization. Lab on a Chip. 2002;2(1):50-5. doi: 10.1039/b109344d. PubMed PMID: WOS:000177954900016
315. Khoury C, Adalsteinson T, Beebe D, Dittmar A, Beebe D. Characterization of protein interaction with tunable microfabricated hydrogels. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:400-5. doi: 10.1109/mmb.2002.1002355. PubMed PMID: WOS:000176123400083
316. Hickman D, Beebe D, Rodriguez-Zas S, Wheeler M. Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. Comparative Medicine. 2002;52(2):122-6. PubMed PMID: WOS:000175291400006
317. Eddington D, Beebe D, IEEE. A hydrogel actuated microdispensing device. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings. 2002:1824-5. doi: 10.1109/iembs.2002.1053045. PubMed PMID: WOS:000180194800899
318. De S, Aluru N, Johnson B, Crone W, Beebe D, Moore J. Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations. Journal of Microelectromechanical Systems. 2002;11(5):544-55. doi: 10.1109/jmems.2002.803281. PubMed PMID: WOS:000178451900018
319. Clark S, Walters E, Beebe D, Wheeler M. In vitro fertilization of porcine oocytes in polydimethylsiloxane (PDMS)-glass microchannels. Biology of Reproduction. 2002;66:312-. PubMed PMID: WOS:000176561900587
320. Beebe D, Mensing G, Walker G. Physics and applications of microfluidics in biology. Annual Review of Biomedical Engineering. 2002;4:261-86. doi: 10.1146/annurev.bioeng.4.112601.125916. PubMed PMID: WOS:000177827800012
321. Bassetti M, Moore J, Beebe D, Dittmar A, Beebe D. Development of electrically triggered hydrogels for microfluidic applications. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:410-3. doi: 10.1109/mmb.2002.1002358. PubMed PMID: WOS:000176123400085
322. Agarwal A, Nammi K, Kaczmarek K, Tyler M, Beebe D, Dittmar A, Beebe D. A hybrid natural/artificial electrostatic actuator for tactile stimulation. 2nd Annual International Ieee-Embs Special Topic Conference on Microtechnologies in Medicine & Biology, Proceedings. 2002:341-5. doi: 10.1109/mmb.2002.1002343. PubMed PMID: WOS:000176123400071
323. Zhao B, Moore J, Beebe D. Surface-directed liquid flow inside microchannels. Science. 2001;291(5506):1023-6. doi: 10.1126/science.291.5506.1023. PubMed PMID: WOS:000166860100040
324. Zerinque H, Beebe D, Wheeler M. Removal of Cumulus from Mammalian Zygotes using Microfluidic Techniques. Biomedical Microdevices. 2001;3(3):219-24. doi: 10.1023/a:1011463330597. PubMed PMID: WOS:000209018700007
325. Tang H, Beebe D, Kramer A. A multilevel input system with force-sensitive elements. International Journal of Human-Computer Studies. 2001;54(4):495-507. doi: 10.1006/ijhc.2000.0451. PubMed PMID: WOS:000168420900002
326. Glasgow I, Zeringue H, Beebe D, Choi S, Lyman J, Chan N, Wheeler M. Handling individual mammalian embryos using microfluidics. Ieee Transactions on Biomedical Engineering. 2001;48(5):570-8. doi: 10.1109/10.918596. PubMed PMID: WOS:000168315200008
327. Eddington D, Liu R, Moore J, Beebe D. An organic self-regulating microfluidic system. Lab on a Chip. 2001;1(2):96-9. doi: 10.1039/b108078d. PubMed PMID: WOS:000179321900004
328. Agarwal A, Kim D, Delisle M, Tang H, Tyler M, Beebe D, IEEE. Two-way communication through an oral-based tactile interface: Preliminary results. Proceedings of the 23rd Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-4. 2001;23:1468-71. PubMed PMID: WOS:000178871900407
329. Olsen M, Bauer J, Beebe D. Particle imaging technique for measuring the deformation rate of hydrogel microstructures. Applied Physics Letters. 2000;76(22):3310-2. doi: 10.1063/1.126635. PubMed PMID: WOS:000087239400051
330. Jo B, Van Lerberghe L, Motsegood K, Beebe D. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. Journal of Microelectromechanical Systems. 2000;9(1):76-81. doi: 10.1109/84.825780. PubMed PMID: WOS:000085857600011
331. Folch A, Jo B, Hurtado O, Beebe D, Toner M. Microfabricated elastomeric stencils for micropatterning cell cultures. Journal of Biomedical Materials Research. 2000;52(2):346-53. doi: 10.1002/1097-4636(200011)52:2<346::aid-jbm14>3.0.co;2-h. PubMed PMID: WOS:000088812900014
332. Beebe D, Moore J, Yu Q, Liu R, Kraft M, Jo B, Devadoss C. Microfluidic tectonics: A comprehensive construction platform for microfluidic systems. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(25):13488-93. doi: 10.1073/pnas.250273097. PubMed PMID: WOS:000165728800009
333. Beebe D, Moore J, Bauer J, Yu Q, Liu R, Devadoss C, Jo B. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature. 2000;404(6778):588-+. doi: 10.1038/35007047. PubMed PMID: WOS:000086400100049
334. Chan N, Lyman J, Choi S, Zeringue H, Glasgow I, Beebe D, Wheeler M. Development of an embryo transport and analysis system: Material biocompatability. Theriogenology. 1999;51(1):234-. doi: 10.1016/s0093-691x(99)91793-4. PubMed PMID: WOS:000077865900094
335. Beebe D, Denton D, Radwin R, Webster J. A silicon-based tactile sensor for finger-mounted applications. Ieee Transactions on Biomedical Engineering. 1998;45(2):151-9. doi: 10.1109/10.661263. PubMed PMID: WOS:000071584700002
336. Beebe D, Hsieh A, Denton D, Radwin R. A silicon force sensor for robotics and medicine. Sensors and Actuators a-Physical. 1995;50(1-2):55-65. doi: 10.1016/0924-4247(96)80085-9. PubMed PMID: WOS:A1995TV42800009
337. BEEBE D, HSIEH A, DENTON D, Sheppard N, Eden M, Kantor G. A FINGER-MOUNTED SILICON TACTILE SENSOR. Proceedings of the 16th Annual International Conference of the Ieee Engineering in Medicine and Biology Society – Engineering Advances: New Opportunities For Biomedical Engineers, Pts 1&2. 1994:834-5. doi: 10.1109/iembs.1994.415169. PubMed PMID: WOS:A1994BC56Q00417
338. BEEBE D, DENTON D. A FLEXIBLE POLYIMIDE-BASED PACKAGE FOR SILICON SENSORS. Sensors and Actuators a-Physical. 1994;44(1):57-64. doi: 10.1016/0924-4247(93)00775-y. PubMed PMID: WOS:A1994PB85500009