Publications

Humayun M, Jiménez-Torres JA, Li C, Ayuso J, Cintron KL, Ulbrich J, Myers B, Kerr SC, Ahmed A, Beebe DJ. Multiplexed luminal tissue constructs with recon1figurable barriers for dynamic modeling of multi-tissue interactions. Adv Mater Technol. 2025 Dec 1:e00429. doi: 10.1002/admt.202500429. Epub ahead of print. PMID: 41693925; PMCID: PMC12900169.

Chao Li, Sue McCrone, Jay W. Warrick, David R. Andes, Zachary Hite, Cecilia F. Volk, Warren E. Rose and David J. Beebe. Under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testing. 2023 Apr 12;23(8):2005-2015.

Li C, Humayun M, Walker GM, Park KY, Connors B, Feng J, Pellitteri Hahn MC, Scarlett CO, Li J, Feng Y, Clark RL, Hefti H, Schrope J, Venturelli OS, Beebe DJ. Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach for Microscale Cell Culture. Adv Sci (Weinh). 2022 Apr;9(10):e2104510. doi: 10.1002/advs.202104510. Epub 2022 Feb 4.

Li C, Niles DJ, Juang DS, Lang JM, Beebe DJ. Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency. SLAS Technol. 2019 Jun 10:2472630319853219. doi: 10.1177/2472630319853219. PMID: 31180792.

Li C, Yu J, Paine P, Juang DS, Berry SM, Beebe DJ. Double-exclusive liquid repellence (double-ELR); an enabling technology for rare phenotype analysis. Lab Chip. 2018 Sep 11; 18(18): 2710-2719. PMID: 30069559.

Pak C, Callander NS, Young EW, Titz B, Kim K, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S. MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells. Integr Biol (Camb). 2015 Jun 8;7(6):643-54. doi: 10.1039/c5ib00071h. Epub 2015 May 22. PMID: 25998180.

Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nature. 2014 Mar 13;507(7491):181-9. PMID: 24622198.

Scott M. Berry, Keil J. Regehr, Benjamin P. Casavant and David J. Beebe. Automated Operation of Immiscible Filtration Assisted by Surface Tension (IFAST) Arrays for Streamlined Analyte Isolation. JALA. Volume 18, Issue 3, June 2013, Pages 206-211.

NCBI list of publications

  1. Humayun M, Jiménez-Torres JA, Li C, Ayuso J, Cintron KL, Ulbrich J, Myers B, Kerr SC, Ahmed A, Beebe DJ. Multiplexed luminal tissue constructs with reconfigurable barriers for dynamic modeling of multi-tissue interactions. Adv Mater Technol. 2025 Dec 1:e00429. doi: 10.1002/admt.202500429. Epub ahead of print. PMID: 41693925; PMCID: PMC12900169.
  2. Kauffman ZJ, Koesser K, Helzer KT, Sharifi MN, Heninger E, Li C, Juang DS, Jarrard DF, Zhao SG, Haffner MC, Beebe DJ, Lang JM, Sperger JM. Lossless Altered Histone Modification Analysis System (LAHMAS). Lab Chip. 2025 Aug 5;25(16):4059-4070. doi: 10.1039/d5lc00060b. PMID: 40620045.
  3. Sánchez-de-Diego C, Yada RC, Sethakorn N, Geiger PG, Ding AB, Heninger E, Ahmed F, Virumbrales-Muñoz M, Lupsa N, Bartels E, Stewart K, Ponik SM, Sharifi MN, Lang JM, Beebe DJ, Kerr SC. Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response. Commun Biol. 2025 Jul 1;8(1):961. doi: 10.1038/s42003-025-08384-2. PMID: 40596459; PMCID: PMC12218145.
  4. Liang NW, Milesh L, Buttram KN, Park JL, Zhang J, Summey LA, Franck C, Beebe DJ, Le HD, Li C. Under-oil neuronal cell culture: Enhanced system stability, yield, and modulated oxygen environment. J Neurosci Methods. 2025 Oct;422:110511. doi: 10.1016/j.jneumeth.2025.110511. Epub 2025 Jun 2. PMID: 40466868.
  5. Babatunde KA, Babatunde OF, Ahmed A, Salgado-Pabon W, Beebe DJ, Kerr SC. Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing. Adv Sci (Weinh). 2025 May 31:e01036. doi: 10.1002/advs.202501036. Epub ahead of print. PMID: 40448602.
  6. Schrope JH, Horn A, Lazorchak K, Tinnen CW, Stevens JJ, Farooqui M, Robertson T, Li J, Bennin D, Juang T, Ahmed A, Li C, Huttenlocher A, Beebe DJ. Confinement by Liquid-Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb-Based Migration. Adv Sci (Weinh). 2025 Jun;12(21):e2414024. doi: 10.1002/advs.202414024. Epub 2025 Mar 28. PMID: 40151891; PMCID: PMC12140350.
  7. Ramírez-Flores CJ, Hryckowian ND, Gale AN, Babatunde KA, Lares M, Beebe DJ, Kerr SC, Knoll LJ. Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system. PLoS Negl Trop Dis. 2025 Feb 4;19(2):e0012855. doi: 10.1371/journal.pntd.0012855. PMID: 39903779; PMCID: PMC12136440.
  8. Magesh S, Schrope JH, Soto NM, Li C, Hurley AI, Huttenlocher A, Beebe DJ, Handelsman J. Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species. Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2417327122. doi: 10.1073/pnas.2417327122. Epub 2025 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2504171122. doi: 10.1073/pnas.2504171122. PMID: 39899715; PMCID: PMC11831133.
  9. Juang DS, Wightman WE, Lozano GL, Juang TD, Barkal LJ, Yu J, Garavito MF, Hurley A, Venturelli OS, Handelsman J, Beebe DJ. Microbial community interactions on a chip. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2403510121. doi: 10.1073/pnas.2403510121. Epub 2024 Sep 17. PMID: 39288179; PMCID: PMC11441501.
  10. Babatunde KA, Datta R, Hendrikse NW, Ayuso JM, Huttenlocher A, Skala MC, Beebe DJ, Kerr SC. Naive primary neutrophils play a dual role in the tumor microenvironment. iScience. 2024 Aug 2;27(9):110632. doi: 10.1016/j.isci.2024.110632. PMID: 39246449; PMCID: PMC11379674.
  11. Juang TD, Riendeau J, Geiger PG, Datta R, Lares M, Yada RC, Singh AM, Seroogy CM, Gern JE, Skala MC, Beebe DJ, Kerr SC. Micro blood analysis technology (μBAT): multiplexed analysis of neutrophil phenotype and function from microliter whole blood samples. Lab Chip. 2024 Aug 20;24(17):4198-4210. doi: 10.1039/d4lc00333k. PMID: 39104301; PMCID: PMC11335436.
  12. Liang NW, Wilson C, Davis B, Wolf I, Qyli T, Moy J, Beebe DJ, Schnapp LM, Kerr SC, Faust HE. Modeling lung endothelial dysfunction in sepsis-associated ARDS using a microphysiological system. Physiol Rep. 2024 Jul;12(13):e16134. doi: 10.14814/phy2.16134. PMID: 38981846; PMCID: PMC11233195.
  13. Giese MA, Bennin DA, Schoen TJ, Peterson AN, Schrope JH, Brand J, Jung HS, Keller NP, Beebe DJ, Dinh HQ, Slukvin II, Huttenlocher A. PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function. J Leukoc Biol. 2024 Jun 28;116(1):118-131. doi: 10.1093/jleuko/qiae039. PMID: 38417030; PMCID: PMC11212797.
  14. Rengarajan A, Goldblatt HE, Beebe DJ, Virumbrales-Muñoz M, Boeldt DS. Immune cells and inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system. Lab Chip. 2024 Mar 12;24(6):1808-1820. doi: 10.1039/d3lc00824j. PMID: 38363157; PMCID: PMC11022267.
  15. Magesh S, Hurley AI, Nepper JF, Chevrette MG, Schrope JH, Li C, Beebe DJ, Handelsman J. Surface colonization by Flavobacterium johnsoniae promotes its survival in a model microbial community. mBio. 2024 Mar 13;15(3):e0342823. doi: 10.1128/mbio.03428-23. Epub 2024 Feb 8. PMID: 38329367; PMCID: PMC10936215.
  16. Chen Q, Zhai H, Beebe DJ, Li C, Wang B. Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions. Nat Commun. 2024 Feb 7;15(1):1155. doi: 10.1038/s41467-024-45076-7. PMID: 38326343; PMCID: PMC10850056.
  17. Li C, Farooqui M, Yada RC, Cai JB, Huttenlocher A, Beebe DJ. The effect of whole blood logistics on neutrophil non-specific activation and kinetics ex vivo. Sci Rep. 2024 Jan 30;14(1):2543. doi: 10.1038/s41598-023-50813-x. PMID: 38291060; PMCID: PMC10828393.
  18. Peterson A, Bennin D, Lasarev M, Chini J, Beebe DJ, Huttenlocher A. Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B. J Cell Sci. 2024 Feb 1;137(3):jcs261774. doi: 10.1242/jcs.261774. Epub 2024 Feb 12. PMID: 38224139; PMCID: PMC10911274.
  19. Abizanda-Campo S, Virumbrales-Muñoz M, Humayun M, Marmol I, Beebe DJ, Ochoa I, Oliván S, Ayuso JM. Microphysiological systems for solid tumor immunotherapy: opportunities and challenges. Microsyst Nanoeng. 2023 Dec 15;9:154. doi: 10.1038/s41378-023-00616-x. PMID: 38106674; PMCID: PMC10724276.
  20. Schrope JH, Horn A, Farooqui M, Lazorchak K, Li J, Tinnen C, Stevens JJ, Bennin D, Robertson T, Juang T, Li C, Huttenlocher A, Beebe DJ. Liquid-liquid interfaces enable tunable cell confinement to recapitulate surrounding tissue deformations during neutrophil interstitial migration in vivo. bioRxiv [Preprint]. 2023 Dec 9:2023.06.14.544898. doi: 10.1101/2023.06.14.544898. PMID: 38106211; PMCID: PMC10723256.
  21. Liang NW, Wilson C, Davis B, Wolf I, Qyli T, Moy J, Beebe DJ, Schnapp LM, Kerr SC, Faust HE. Modeling Sepsis-Associated ARDS Using a Lung Endothelial Microphysiological System. bioRxiv [Preprint]. 2023 Oct 10:2023.10.10.561102. doi: 10.1101/2023.10.10.561102. Update in: Physiol Rep. 2024 Jul;12(13):e16134. doi: 10.14814/phy2.16134. PMID: 37873450; PMCID: PMC10592774.
  22. Ayuso JM, Farooqui M, Virumbrales-Muñoz M, Denecke K, Rehman S, Schmitz R, Guerrero JF, Sanchez-de-Diego C, Campo SA, Maly EM, Forsberg MH, Kerr SC, Striker R, Sherer NM, Harari PM, Capitini CM, Skala MC, Beebe DJ. Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nat Commun. 2023 Oct 21;14(1):6681. doi: 10.1038/s41467-023-41625-8. Erratum in: Nat Commun. 2023 Nov 10;14(1):7292. doi: 10.1038/s41467-023-43057-w. PMID: 37865647; PMCID: PMC10590421.
  23. Sanchez-de-Diego C, Virumbrales-Muñoz M, Hermes B, Juang TD, Juang DS, Riendeau J, Guzman EC, Reed-McBain CA, Abizanda-Campo S, Patel J, Hess NJ, Skala MC, Beebe DJ, Ayuso JM. Griddient: a microfluidic array to generate reconfigurable gradients on-demand for spatial biology applications. Commun Biol. 2023 Sep 9;6(1):925. doi: 10.1038/s42003-023-05282-3. PMID: 37689746; PMCID: PMC10492845.
  24. Li C, McCrone S, Warrick JW, Andes DR, Hite Z, Volk CF, Rose WE, Beebe DJ. Under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testing. Lab Chip. 2023 Apr 12;23(8):2005-2015. doi10.1039/d3lc00066d. PMID: 36883560.
  25. McMinn PH, Ahmed A, Huttenlocher A, Beebe DJ, Kerr SC. The lymphatic endothelium-derived follistatin: activin A axis regulates neutrophil motility in response to Pseudomonas aeruginosa. Integr Biol (Camb). 2023 Apr 11;15:zyad003. doi: 10.1093/intbio/zyad003. PMID: 36781971.
  26. Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W, Beltran H, Choueiri TK, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE, Taplin ME, Lang JM. A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer. J ClinInvest. 2022 Nov 1;132(21):e161858. doi: 10.1172/JCI161858. PMID: 36317634; PMCID: PMC9621140.
  27. Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM. Enhanced Ribonucleoprotein Immunoprecipitation (RIP) Technique for the Identification of mRNA Species in Ribonucleoprotein Complexes. Bio Protoc. 2022 Oct 5;12(19):e4526. doi: 10.21769/BioProtoc.4526. PMID: 36313200; PMCID: PMC9548516.
  28. Sethakorn N, Heninger E, Breneman MT, Recchia E, Ding AB, Jarrard DF, Hematti P, Beebe DJ, Kosoff D. Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform. FASEB J. 2022 Oct;36(10):e22540. doi: 10.1096/fj.202200684RR. PMID: 36083096; PMCID: PMC9476232.
  29. Rodems TS, Heninger E, Stahlfeld CN, Gilsdorf CS, Carlson KN, Kircher MR, Singh A, Krueger TEG, Beebe DJ, Jarrard DF, McNeel DG, Haffner MC, Lang JM. Reversible epigenetic alterations regulate class I HLA loss in prostate cancer. Commun Biol. 2022 Sep 1;5(1):897. doi: 10.1038/s42003-022-03843-6. PMID: 36050516; PMCID: PMC9437063.
  30. Simitian G, Virumbrales-Munoz M, Sanchez-de-Diego C, Beebe DJ, Kosoff D. Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians. Lab Chip. 2022 Sep 27;22(19):3618-3636. doi:10.1039/d2lc00352j. PMID: 36047330; PMCID: PMC9530010.
  31. Juang DS, Juang TD, Dudley DM, Newman CM, Accola MA, Rehrauer WM, Friedrich TC, O’Connor DH, Beebe DJ. Oil immersed lossless total analysis system for integrated RNA extraction and detection of SARS-CoV-2. Nat Commun. 2021 Jul 14;12(1):4317.
  32. Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O’Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin N, Burkard. Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.Mol Cancer Ther. 2021 Dec;20(12):2553-2567. doi: 10.1158/1535-7163.MCT-21-0195. Epub 2021 Sep 28.
  33. Li C, Hurley A, Hu W, Warrick JW, Lozano GL, Ayuso JM, Pan W, Handelsman J, Beebe DJ. Social motility of biofilm-like microcolonies in a gliding bacterium. Nat Commun. 2021 Sep 29;12(1):5700. doi: 10.1038/s41467-021-25408-7.
  34. Babatunde KA, Ayuso JM, Kerr SC, Huttenlocher A, Beebe DJ. Microfluidic Systems to Study Neutrophil Forward and Reverse Migration. Front Immunol. 2021 Nov 24;12:781535. doi: 10.3389/fimmu.2021.781535. eCollection 2021.
  35. Lugo-Cintrón KM, Ayuso JM, Humayun M, Gong MM, Kerr SC, Ponik SM, Harari PM, Virumbrales-Muñoz M, Beebe DJ. Primary head and neck tumour-derived fibroblasts promote lymphangiogenesis in a lymphatic organotypic co-culture model. 2021 Nov;73:103634. doi: 10.1016/j.ebiom.2021.103634. Epub 2021 Oct 18.
  36. Heninger E, Kosoff D, Rodems TS, Sethakorn N, Singh A, Gungurthi H, Carlson KN, Yang B, Gilsdorf C, Pasch CA, Deming DA, Ellis L, Beebe DJ, Jarrard DF, Lang JM. Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling. Med Oncol. 2021 Sep 28;38(11):135.
  37. van Steen ACI, Kempers L, Schoppmeyer R, Blokker M, Beebe DJ, Nolte MA, van Buul JD. Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix. J Cell Sci. 2021 Nov 1;134(21):jcs258690. doi: 10.1242/jcs.258690. Epub 2021 Nov 4.
  38. Park KY, Hefti HO, Liu P, Lugo-Cintrón KM, Kerr SC, Beebe DJ. Immune cell mediated cabozantinib resistance for patients with renal cell carcinoma. Integr Biol (Camb). 2021 Dec 30;13(11):259-268.
  39. Sethakorn N, Heninger E, Sánchez-de-Diego C, Ding AB, Yada RC, Kerr SC, Kosoff D, Beebe DJ, Lang JM. Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment. Cancers (Basel). 2022 Feb 1;14(3):757. doi: 10.3390/cancers14030757.
  40. Vitek RA, Huang W, Geiger PG, Heninger E, Lang JM, Jarrard DF, Beebe DJ, Johnson BP. Fresh tissue procurement and preparation for multicompartment and multimodal analysis of the prostate tumor microenvironment. 2022 May;82(7):836-849. doi: 10.1002/pros.24326. Epub 2022 Feb 28.
  41. Virumbrales-Muñoz M, Ayuso JM, Loken JR, Denecke KM, Rehman S, Skala MC, Abel EJ, Beebe DJ. Microphysiological model of renal cell carcinoma to inform anti-angiogenic therapy. 2022 Apr;283:121454. doi: 10.1016/j.biomaterials.2022.121454. Epub 2022 Mar 11.
  42. Shapiro DD, Virumbrales-Muñoz M, Beebe DJ, Abel EJ. Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics. Front Oncol. 2022 Apr 7;12:871252. doi: 10.3389/fonc.2022.871252. eCollection 2022.
  43. Rodems TS, Juang DS, Stahlfeld CN, Gilsdorf CS, Krueger TEG, Heninger E, Zhao SG, Sperger JM, Beebe DJ, Haffner MC, Lang JM. SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples. Clin Epigenetics. 2022 Mar 10;14(1):37. doi: 10.1186/s13148-022-01252-4.
  44. Fakhraldeen SA, Berry SM, Beebe DJ, Roopra A, Bisbach CM, Spiegelman VS, Niemi NM, Alexander CM. Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells. J Biol Chem. 2022 Mar;298(3):101649. doi: 10.1016/j.jbc.2022.101649. Epub 2022 Jan 29.
  45. Schehr JL, Sethakorn N, Schultz ZD, Hernandez CI, Bade RM, Eyzaguirre D, Singh A, Niles DJ, Henderson L, Warrick JW, Berry SM, Sundling KE, Beebe DJ, Leal TA, Lang JM. Analytical validation and initial clinical testing of quantitative microscopic evaluation for PD-L1 and HLA I expression on circulating tumor cells from patients with non-small cell lung cancer. Biomark Res. 2022 Apr 25;10(1):26. doi: 10.1186/s40364-022-00370-8.
  46. Juang DS, Lang JM, Beebe DJ. Volumeless reagent delivery: a liquid handling method for adding reagents to microscale droplets without increasing volume. Lab Chip. 2022 Jan 18;22(2):286-295. doi: 10.1039/d1lc00906k.
  47. Sadangi S, Milosavljevic K, Castro-Perez E, Lares M, Singh M, Altameemi S, Beebe DJ, Ayuso JM, Setaluri V Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes. Cancers (Basel). 2022 Feb 27;14(5):1233. doi: 10.3390/cancers14051233.
  48. Li C, Humayun M, Walker GM, Park KY, Connors B, Feng J, Pellitteri Hahn MC, Scarlett CO, Li J, Feng Y, Clark RL, Hefti H, Schrope J, Venturelli OS, Beebe DJ. Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach for Microscale Cell Culture. Adv Sci (Weinh). 2022 Apr;9(10):e2104510. doi: 10.1002/advs.202104510. Epub 2022 Feb 4.
  49. Juang DS, Juang TD, Dudley DM, Newman CM, Accola MA, Rehrauer WM, Friedrich TC, O’Connor DH, Beebe DJ. Oil immersed lossless total analysis system for integrated RNA extraction and detection of SARS-CoV-2. Nat Commun. 2021 Jul 14;12(1):4317. doi: 10.1038/s41467-021-24463-4. PMID: 34262053; PMCID:PMC8280165.
  50. Hind LE, Giese MA, Schoen TJ, Beebe DJ, Keller N, Huttenlocher A. Immune Cell Paracrine Signaling Drives the Neutrophil Response to <i>A. fumigatus</i> in an Infection-on-a-Chip Model. Cell Mol Bioeng. 2020 Oct 13;14(2):133-145. doi: 10.1007/s12195-020-00655-8. PMID: 33868496; PMCID: PMC8010091.
  51. Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Basu H, Beebe DJ. A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment. Integr Biol (Camb). 2021 Apr 20;13(4):87-97. doi: 10.1093/intbio/zyab004. PMID: 33822934.
  52. Johnson BP, Vitek RA, Morgan MM, Fink DM, Beames TG, Geiger PG, Beebe DJ, Lipinski RJ. A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development. Front Cell Dev Biol. 2021 Feb 9; 9:621442. doi: 10.3389/fcell.2021.621442. PMID: 33634122; PMCID: PMC7900501.
  53. Bade RM, Schehr JL, Emamekhoo H, Gibbs BK, Rodems TS, Mannino MC, Desotelle JA, Heninger E, Stahlfeld CN, Sperger JM, Singh A, Wolfe SK, Niles DJ, Arafat W, Steinharter JA, Jason Abel E, Beebe DJ, Wei XX, McKay RR, Choueri TK, Lang JM. Development and initial clinical testing of a multiplexed circulating tumor cell assay in patients with clear cell renal cell carcinoma. Mol Oncol. 2021 Feb 19. doi: 10.1002/1878-0261.12931. Epub ahead of print. PMID: 33604999.
  54. Ayuso JM, Rehman S, Virumbrales-Munoz M, McMinn PH, Geiger P, Fitzgerald C, Heaster T, Skala MC, Beebe DJ. Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion. Sci Adv. 2021 Feb 17;7(8):eabc2331. doi: 10.1126/sciadv.abc2331. PMID: 33597234; PMCID: PMC7888951.
  55. Humayun M, Ayuso JM, Brenneke RA, Virumbrales-Muñoz M, Lugo-Cintrón K, Kerr S, Ponik SM, Beebe DJ. Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model. Biomaterials. 2021 Mar;270:120640. doi: 10.1016/j.biomaterials.2020.120640. Epub 2021 Feb 6. PMID: 33592387.
  56. Ayuso JM, Sadangi S, Lares M, Rehman S, Humayun M, Denecke KM, Skala MC, Beebe DJ, Setaluri V. Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism. Lab Chip. 2021 Mar 21;21(6):1139-1149. doi: 10.1039/d0lc00988a. Epub 2021 Feb 3. PMID: 33533390; PMCID: PMC7990711.
  57. Ayuso JM, Park KY, Virumbrales-Muñoz M, Beebe DJ. Toward improved <i>in vitro</i> models of human cancer. APL Bioeng. 2021 Jan 21;5(1):010902. doi: 10.1063/5.0026857. PMID: 33532672; PMCID: PMC7822630.
  58. Ayuso JM, Rehman S, Farooqui M, Virumbrales-Muñoz M, Setaluri V, Skala MC, Beebe DJ. Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. Int J Mol Sci. 2020 Nov 28;21(23):9075. doi: 10.3390/ijms21239075. PMID: 33260673; PMCID: PMC7730115.
  59. Virumbrales-Muñoz M, Chen J, Ayuso JM, Lee Moonhee, Abel, Beebe DJ. Organotypic primary blood vessel models of clear cell renal cell carcinoma for single-patient clinical trials. Lab Chip. 2020 Oct 26.doi: 10.1039/d0lc00252f. Online ahead of print.
  60. Heaster TM, Humayun M, Yu J, Beebe DJ, Skala MC. Autoflourescence imaging of 3D tumor-macrophage microscale cultures resolves spatial and temporal dynamics of macrophage metabolism. Cancer Res. 2020 Oct 22;canres.0831.2020. doi: 10.1158/0008-5472.CAN-20-0831. Online ahead of print.
  61. Kerr SC, Morgan MM, Gillette AA, Livingston MK, Lugo-Cintron KM, Favreau PF, Florek L, Johnson BP, Lang JM, Skala MC, Beebe DJ. A bioengineered organotypic prostate model for the study of tumor microenvironment-induced immune cell activation. Integr Biol (Camb). 2020 Oct 16;12(10):250-262. doi: 10.1093/intbio/zyaa020.
  62. Virumbrales-Muñoz M, Ayuso JM, Gong MM, Humayun M, Livingston MK, Lugo-Cintrón KM, McMinn P, Álvarez-García YR, Beebe DJ. Microfluidic lumen-based systems for advancing tubular organ modeling. Chem Soc Rev. 2020 Aug 6. doi: 10.1039/d0cs00705f. Online ahead of print.PMID: 32760967
  63. Kaushik G, Gupta K, Harms V, Torr E, Evans J, Johnson HJ, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D, Uhl P, Johnson BP, Palecek SP, Beebe DJ, Thomson JA, Daly WT, Murphy WL. Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity. Adv Healthc Mater. 2020 Jul 1:e2000825. doi: 10.1002/adhm.202000825. Online ahead of print.PMID: 32613760
  64. McMinn P, Guckenberger DJ, Beebe DJ. Induced Pluripotent Stem Cells on a Chip: A Self-Contained, Accessible, Pipette-less iPSC Culturing and Differentiation Kit. SLAS Technol. 2020 Jun 19:2472630320921173. doi: 10.1177/2472630320921173. Online ahead of print.
  65. Li C, Hite Z, Warrick JW, Li J, Geller SH, Trantow VG, McClean MN, Beebe DJ. Under oil open-channel microfluidics empowered by exclusive liquid repellency. Sci Adv. 2020 Apr 17;6(16):eaay9919. doi: 10.1126/sciadv.aay9919. eCollection 2020 Apr.PMID: 32494607
  66. Lugo-Cintrón KM, Gong MM, Ayuso JM, Tomko LA, Beebe DJ, Virumbrales-Muñoz M, Ponik SM. Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration Through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model. Cancers (Basel). 2020 May 6;12(5):1173. doi: 10.3390/cancers12051173.PMID: 32384738
  67. Lugo-Cintrón KM, Ayuso JM, White BR, Harari PM, Ponik SM, Beebe DJ, Gong MM, Virumbrales-Muñoz M. Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment. Lab Chip. 2020 May 7;20(9):1586-1600. doi: 10.1039/d0lc00099j. Epub 2020 Apr 16.PMID: 32297896
  68. Morgan MM, Schuler LA, Ciciliano JC, Johnson BP, Alarid ET, Beebe DJ. Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro. Integr Biol (Camb). 2020 Mar 6;12(2):21-33. doi: 10.1093/intbio/zyaa002.PMID: 32118264
  69. Whitt J, Hong WS, Telange RR, Lin CP, Bibb J, Beebe DJ, Chen H, Jaskula-Sztul R. Non-toxic fragment of botulinum neurotoxin type A and monomethyl auristatin E conjugate for targeted therapy for neuroendocrine tumors. Cancer Gene Ther. 2020 Feb 7. doi: 10.1038/s41417-020-0167-x. [Epub ahead of print] PMID:32029905
  70. Tokar JJ, Stahlfield CN, Sperger JM, Niles DJ, Beebe DJ, Lang, JM, Warrick JW. Pairing Microwell Arrays with an Affordable, Semiautomated Single Cell Aspirator for the Interrogation of Circulating Tumor Cell Heterogeneity. SLAS Technol. 2020 Jan 26:2472630319898146. doi: 10.1177/2472630319898146. [Epub ahead of print]
  71. Ayuso JM, Gong MM, Skala MC, Harari PM, Beebe DJ. Human Tumor-Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Adv.Healthc. Mater. 2020 Jan1. e1900925. doi: 10.1002/adhm.201900925. [Epub ahead of print]
  72. Livingston MK, Morgan MM, Daly WT,m Murphy WL, Johnson BP, Beebe DJ, Virumbrales-Munoz M. Evaluation of PEG-based hydrogel influence on estrogen receptor driven responses in MCF7 breast cancer cells. ACS Biomater Sci Eng. 2019;5(11):6089-6098.
  73. Virumbrales-Munoz M, Livingston MK, Farooqui M, Skala MC, Beebe DJ, Ayuso JM. Development of a Microfluidic Array to Study Drug Response in Breast Cancer. Molecules. 2019 Nov 30;24(23).
  74. McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control. Lab Chip. 2019 Oct 2. doi: 10.1039/c9lc00562e. [Epub ahead of print]
  75. Ayuso JM, Virumbrales-Munoz M, McMinn PH, Rehman S, Gomez I, Karim MR, Truttschel R, Wisinski KB, Beebe DJ, Skala MC. Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. Lab Chip. 2019 Sep 11. doi: 10.1039/c9lc00270g. [Epub ahead of print]
  76. Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ. Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells. Sci Rep. 2019 Aug 28:9(1):12480. 12480. doi: 10.1038/s41598-019-48764-3.PMID: 31462653.
  77. Yu J, Berthier E, Craig A, de Groot TE, Sparks S, Ingram PN, Jarrard DF, Huang W, Beebe DJ, Theberge AB. Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signaling. Nat Biomed Eng. 2019 Aug 19. doi: 10.1038/s41551-019-0421-4. PMID: 31427781
  78. Juang DS, Berry SM, Li C, Lang JM, Beebe DJ. Centrifugation-Assisted Immiscible Fluid Filtration for Dual Bioanalyte Extraction. Anal Chem. 2019 Aug 26. doi: 10.1021/acs.analchem.9b02572. PMID: 31411020.
  79. Gong MM, Lugo-Cintron KM, White BR, Kerr SC, Harari PM, Beebe DJ. Human organotypic lymphatic vessel model elucidates microenvironment-dependent signaling and barrier function. 2019 Sep;214:119225. doi: 10.1016/j.biomaterials.2019.119225. Epub 2019 May 25. PMID: 31154151.
  80. Seenivasan R, Warrick JW, Rodriguez CI, Mattison W, Beebe DJ, Setaluri V, Gunasekaran S. Integrating Electrochemical Immunosensing and Cell Adhesion Technologies for Cancer Cell Detection and Enumeration. Seenivasan R, Warrick JW, Rodriguez CI, Mattison W, Beebe DJ, Setaluri V, Gunasekaran S. Electrochim Acta. 2018 Oct 1;286:205-211. doi: 10.1016/j.electacta.2018.08.005. Epub 2018 Aug 4. PMID: 31130739.
  81. Regier MC, Olszewski E, Carter CC, Aitchison JD, Kaushansky A, Davis J, Berthier E, Beebe DJ, Stevens KR. Spatial presentation of biological molecules to cells by localized diffusive transfer. Lab Chip. 2019 Jun 11;19(12):2114-2126. doi: 10.1039/c9lc00122k. PMID: 31111131.
  82. Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR. User-defined morphogen patterning for directing human cell fate stratification. Sci Rep. 2019 Apr 23;9(1):6433. doi: 10.1038/s41598-019-42874-8. PMID: 31015521.
  83. Morgan MM, Arendt LM, Alarid ET, Beebe DJ, Johnson BP. Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model. FASEB J. 2019 Jul;33(7):8623-8633. doi: 10.1096/fj.201802347RRR. Epub 2019 Apr 19. PMID: 31002529.
  84. Li C, Niles DJ, Juang DS, Lang JM, Beebe DJ. Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency. SLAS Technol. 2019 Jun 10:2472630319853219. doi: 10.1177/2472630319853219. [Epub ahead of print]. PMID: 31180792.
  85. Virumbrales-Muñoz M, Ayuso JM, Lacueva A, Randelovic T, Livingston MK, Beebe DJ, Oliván S, Pereboom D, Doblare M, Fernández L, Ochoa I. Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling. Sci Rep. 2019 Apr 17;9(1):6199. doi: 10.1038/s41598-019-42529-8. PMID: 30996291.
  86. Jiménez-Torres JA, Virumbrales-Muñoz M, Sung KE, Lee MH, Abel EJ, Beebe DJ. Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma. 2019 Apr;42:408-419. doi: 10.1016/j.ebiom.2019.03.026. Epub 2019 Mar 20. PMID: 30902740.
  87. Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC. Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. 2018 Dec 12;8(3):1553477. doi: 10.1080/2162402X.2018.1553477. eCollection 2019. PMID: 30723584.
  88. Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedo S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ. Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. 2018 Nov;37:144-157. doi: 10.1016/j.ebiom.2018.10.046. Epub 2018 Oct 26. PMID: 30482722.
  89. Pezzi HM, Guckenberger DJ, Schehr JL, Rothbauer J, Stahlfeld C, Singh A, Horn S, Schultz ZD, Bade RM, Sperger JM, Berry SM, Lang JM, Beebe DJ. Versatile exclusion-based sample preparation platform for integrated rare cell isolation and analyte extraction. Lab Chip. 2018 Nov 6;18(22):3446-3458. doi: 10.1039/c8lc00620b. PMID: 30334061.
  90. Álvarez-García YR, Ramos-Cruz KP, Agostini-Infanzón RJ, Stallcop LE, Beebe DJ, Warrick JW, Domenech M. Open multi-culture platform for simple and flexible study of multi-cell type interactions. Lab Chip. 2018 Oct 9;18(20):3184-3195. doi: 10.1039/c8lc00560e. PMID: 30204194.
  91. Li C, Yu J, Schehr J, Berry SM, Leal TA, Lang JM, Beebe DJ. Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing. ACS Appl Mater Interfaces. 2018 May 23;10(20):17065-17070. doi: 10.1021/acsami.8b03627. Epub 2018 May 8.
  92. Álvarez-García YR, Ramos-Cruz KP, Agostini-Infanzón RJ, Stallcop LE, Beebe DJ, Warrick JW, Domenech M. Open multi-culture platform for simple and flexible study of multi-cell type interactions. Lab Chip. 2018 Sep 11. doi: 10.1039/c8lc00560e. [Epub ahead of print]. PMID: 30204194
  93. Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P. aeruginosa. 2018 Aug 24. pii: blood-2018-05-848465. doi: 10.1182/blood-2018-05-848465. [Epub ahead of print]
  94. Kosoff D, Yu J, Suresh V, Beebe DJ, Lang JM. Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems. Lab Chip. 2018 Aug 22. doi: 10.1039/c8lc00431e. [Epub ahead of print]PMID: 30131982
  95. Li C, Yu J, Paine P, Juang DS, Berry SM, Beebe DJ. Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis. Lab Chip. 2018 Aug 2. doi: 10.1039/c8lc00584b. PMID 30069559
  96. Johnson BP, Vitek RA, Geiger PG, Huang W, Jarrard DF, Lang JM, Beebe DJ. Vital ex vivo tissue labeling and pathology-guided micropunching to characterize cellular heterogeneity in the tissue microenvironment. 2018 Jan 1;64(1):13-19. doi: 10.2144/000114626. PMID: 29384072.
  97. Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ.  An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.Adv Healthc Mater. 2018 Jan;7(2). doi: 10/1002/adhm.201700497. PMID 29364596.
  98. Poenitzsch Strong AM, Berry SM, Beebe DJ, Li JL, Spiegelman VS. miFAST: A novel and rapid microRNA target capture method.Lab Chip. 2018 Jan 30; 18(3):451-462. doi: 10.1039/c7Ic00724h. PMID 29318250.
  99. Stallcop LE, Álvarez-García YR, Reyes-Ramos AM, Ramos-Cruz KP, Morgan MM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW. Razor-printed sticker microdevices for cell-based applications.Lab Chip. 2018 Jan 30;18(3):451-462. doi: 10.1039/c7lc00724h. PMID: 29318250.
  100. Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ. Microbial volatile communication in human organotypic lung models.Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4. PMID: 29176665.
  101. Pezzi HM, Berry SM, Beebe DJ, Striker R. RNA-mediated TILDA for improved cell capacity and enhanced detection of multiply-spliced HIV RNA.Integr Biol (Camb). 2017 Nov 13;9(11):876-884. doi: 10.1039/c7ib00112f. PMID: 29098230.
  102. Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF. Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. PMID: 29073104.
  103. Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ. Multikingdom microscale models. PLoS Pathog. 2017 Aug 24; 13(8): e1006424. doi: 10.1371/journal/ppat.1006424. PMID: 28837694.
  104. Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttnelocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078. PMID: 28528177
  105. Tokar JJ, Warrick JW, Guckenberger DJ, Sperger JM, Lang JM, Ferguson JS, Beebe DJ. Interrogating Bronchoalveolar Lavage Samples via Exclusion-Based Analyte Extraction. SLAS Technol. 2017 Jun 22(3): 348-357. doi: 10.1177/2472630317696780. Epub 2017 Mar 15. PMID: 28298147
  106. Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE. The Influence of Biomaterials on Cytokine Production in 3D Cultures. Biomacromolecules. 2017 Mar 13; 18(3): 709-18. doi: 10.1021/acs.biomac.6b01469. Epub 2017 Feb 16. PMID: 28157290
  107. Johnson CJ, Cabezas-Olcoz J, Kemien JF, Wang SX, Beebe DJ, Huttenlocher A, Ansari H, Nett JE. The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps. PLoS Pathog. 2016 Sep 13; 12(9)e1005884. doi: 10.1371/journal.ppat.1005884. PMID: 27622514
  108. Guckenberger DJ, Pezzi HM, Regier MC, Berry SM, Fawcett K, Barrett K, Beebe DJ. A magnetic system for automated manipulation of paramagnetic particles.Anal Chem. Epub 2016 Sep 6.  PMID: 2759885
  109. Jiménez-Torres JA, Beebe DJ, Sung KE. A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment.Methods Mol Biol. 2016;1458:59-69. doi: 10.1007/978-1-4939-3801-8_5. PMID: 2758101
  110. Regier MC, Maccoux LJ, Weinberger EM, Regehr KJ, Berry SM, Beebe DJ, Alarid ET.  Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments.Biomed Microdevices. 2016 Aug;18(4):70. doi: 10.1007/s10544-016-0083-x. PMID: 2743232
  111. Schehr JL, Schultz ZD, Warrick JW, Guckenberger DJ, Pezzi HM, Sperger JM, Heninger E, Saeed A, Leal T, Mattox K, Traynor AM, Campbell TC, Berry SM, Beebe DJ, Lang JM. High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1. PLoS One. 2016 Jul 26;11(7):e0159397. doi: 10.1371/journal.pone.0159397. eCollection 2016. PMID: 2745954
  112. Sperger JM, Strotman LN, Welsh A, Casavant BP, Chalmers Z, Horn S, Heninger E, Thiede S, Tokar J, Gibbs BK, Guckenberger DJ, Carmichael L, Dehm SM, Stephens PJ, Beebe DJ, Berry SM, Lang JM. Integrated analysis of multiple biomarkers from circulating tumor cells enabled by exclusion-based analyte isolation.Clin Cancer Res. 2016 Jul 11. pii: clincanres.1021.2016. [Epub ahead of print] PMID: 2740124
  113. Regier MC, Alarid ET, Beebe DJ. Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.Integr Biol (Camb). 2016 Jun 13;8(6):684-92. doi: 10.1039/c6ib00001k. Epub 2016 Apr 21. PubMed PMID: 27097801
  114. Berry SM, Pezzi HM, LaVanway AJ, Guckenberger DJ, Anderson MA, Beebe DJ. AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions.ACS Appl Mater Interfaces. 2016 Jun 10. [Epub ahead of print] PubMed Central PMCID: 5058634.
  115. Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ. Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.Pharmacol Ther. 2016 May 21. pii: S0163-7258(16)30078-X. doi: 10.1016/j.pharmthera.2016.05.007. [Epub ahead of print] Review. PubMed PMID: 27218886.
  116. Barkal LJ, Walsh NM, Botts MR, Beebe DJ, Hull CM. Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination.Integr Biol (Camb). 2016 May 16;8(5):603-15. doi: 10.1039/c6ib00012f. Epub 2016 Mar 30. PubMed PMID: 27026574; PubMed Central PMCID: PMC4868663
  117. Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels.Acta Biomater. 2016. doi: 10.1016/j.actbio.2016.03.001. PubMed PMID: 26945632
  118. Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang CC, Beebe DJ, Keller NP, Berthier E. Microbial metabolomics in open microscale platforms.Nat Commun. 2016 Feb 4;7:10610. doi: 10.1038/ncomms10610. PubMed PMID: 26842393.
  119. Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW, Guckenberger DJ, Huttenlocher A, Beebe DJ. Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.Integr Biol (Camb). 2016 Feb 15;8(2):243-52. doi: 10.1039/c5ib00225g. Epub 2016 Jan 25. PubMed PMID: 26805445.
  120. Jiménez-Torres JA, Peery SL, Sung KE, Beebe DJ. LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater. 2016 Jan;5(2):198-204. doi: 10.1002/adhm.201500608. Epub 2015 Nov 26. PubMed PMID: 26610188.
  121. Hong, WS, Pezzi HM, Schuster AR, Berry SM, Sung KE, Beebe DJ.  Development of a Highly Sensitive Cell-Based Assay for Detecting Botulinum Neurotoxin Type A through Neural Culture Media Optimization.J Biomol Screen. 2016 Jan;21(1):65-73. doi: 10.1177/1087057115608103. PubMed PMID: 26420788.
  122. Khnouf R, Chapman B, Jin S, Beebe DJ, Fan ZH. Detection of ricin in beverages using cell-free protein synthesis in a microfluidic device.Sensors and Actuators B: Chemical. 2015; Dec; 221:723-729. doi:10.1016/j.snb.2015.06.077.
  123. de Groot TE, Veserat KS, Berthier E, Beebe DJ, Theberge AB. Surface-tension driven open microfluidic platform for hanging droplet culture.Lab Chip. 2015 Dec 11. [Epub ahead of print] PubMed PMID: 26660268.
  124. Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A. Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D.Biomed Microdevices. 2015 Oct;17(5):100. doi: 10.1007/s10544-015-9998-x. PubMed PMID: 26354879; PubMed Central PMCID: PMC4678772.
  125. Pak C, Callander NS, Young EW, Titz B, Kim K, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S. MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells.Integr Biol (Camb). 2015 Jun 8;7(6):643-54. doi: 10.1039/c5ib00071h. Epub 2015 May 22. PubMed PMID: 25998180; PubMed Central PMCID: PMC4476551.
  126. Guckenberger DJ, de Groot TE, Wan AM, Beebe DJ, Young EW. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices.Lab Chip. 2015 Jun 7;15(11):2364-78. doi: 10.1039/c5lc00234f. PubMed PMID: 25906246; PubMed Central PMCID: PMC4439323.
  127. Moussavi-Harami SF, Pezzi HM, Huttenlocher A, Beebe DJ. Simple microfluidic device for studying chemotaxis in response to dual gradients.Biomed Microdevices. 2015 Jun;17(3):9955. doi: 10.1007/s10544-015-9955-8. PubMed PMID: 25893484.
  128. Theberge AB, Yu J, Young EW, Ricke WA, Bushman W, Beebe DJ. Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis.Anal Chem. 2015 Mar 17;87(6):3239-46. doi: 10.1021/ac503700f. Epub 2015 Feb 26. PubMed PMID: 25719435; PubMed Central PMCID: PMC4405103.
  129. Bischel LL, Beebe DJ, Sung KE. Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure. BMC Cancer. 2015. Jan 21; 15:12. doi: 10.1186/s12885-015-1007-5. PubMed PMID: 25605670; PubMed Central PMCID: PMC4305264.
  130. Powers GL, Hammer KD, Domenech M, Frantskevich K, Malinowski RL, Bushman W, Beebe DJ, Marker PC. Phosphodiesterase 4D inhibitors limit prostate cancer growth potential. Molecular cancer research : MCR. 2015;13(1):149-60. Epub 2014/08/26. doi: 10.1158/1541-7786.MCR-14-0110. PubMed PMID: 25149359; 4312503
  131. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2015;72(2):237-49. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
  132. Sung KE, Beebe DJ. Microfluidic 3D models of cancer. Adv Drug Deliv Rev. 2014;79-80:68-78. Epub 2014/07/16. doi: 10.1016/j.addr.2014.07.002. PubMed PMID: 25017040; 4258433
  133. Shelef M, Sokolove J, Lahey L, Wagner C, Sackmann E, Warner T, Wang Y, Beebe D, Robinson W, Huttenlocher A. Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor alpha-Induced Inflammatory Arthritis. Arthritis & Rheumatology. 2014;66(6):1482-91. doi: 10.1002/art.38393. PubMed PMID: WOS:000337366200010
  134. Sackmann E, Fulton A, Beebe D. The present and future role of microfluidics in biomedical research. Nature. 2014;507(7491):181-9. doi: 10.1038/nature13118. PubMed PMID: WOS:000332651800029
  135. Sackmann E, Berthier E, Schwantes E, Fichtinger P, Evans M, Dziadzio L, Huttenlocher A, Mathur S, Beebe D. Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(16):5813-8. doi: 10.1073/pnas.1324043111. PubMed PMID: WOS:000334694000032
  136. Montanez-Sauri SI, Beebe DJ, Sung KE. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 2014. Epub 2014/10/03. doi: 10.1007/s00018-014-1738-5. PubMed PMID: 25274061
  137. Howard A, Pezzi H, Beebe D, Berry S. Exclusion-Based Capture and Enumeration of CD4(+) T Cells from Whole Blood for Low-Resource Settings. Jala. 2014;19(3):313-21. doi: 10.1177/2211068213509248. PubMed PMID: WOS:000336267600010
  138. Guckenberger D, Thomas P, Rothbauer J, LaVanway A, Anderson M, Gilson D, Fawcett K, Berto T, Barrett K, Beebe D, Berry S. A Combined Fabrication and Instrumentation Platform for Sample Preparation. Jala. 2014;19(3):267-74. doi: 10.1177/2211068213518312. PubMed PMID: WOS:000336267600005
  139. Guckenberger D, Berthier E, Young E, Beebe D. Fluorescence-Based Assessment of Plasma-Induced Hydrophilicity in Microfluidic Devices via Nile Red Adsorption and Depletion. Analytical Chemistry. 2014;86(15):7258-63. doi: 10.1021/ac501259n. PubMed PMID: WOS:000340081100018
  140. Fan Z, Beebe D. Lab on a chip and circulating tumor cells. Lab on a Chip. 2014;14(1):12-3. doi: 10.1039/c3lc90125d. PubMed PMID: WOS:000327669000001
  141. Casavant B, Strotman L, Tokar J, Thiede S, Traynor A, Ferguson J, Lang J, Beebe D. Paired diagnostic and pharmacodynamic analysis of rare non-small cell lung cancer cells enabled by the VerIFAST platform. Lab on a Chip. 2014;14(1):99-105. doi: 10.1039/c3lc50912e. PubMed PMID: WOS:000327669000010
  142. Casavant B, Guckenberger D, Beebe D, Berry S. Efficient Sample Preparation from Complex Biological Samples Using a Sliding Lid for Immobilized Droplet Extractions. Analytical Chemistry. 2014;86(13):6355-62. doi: 10.1021/ac500574t. PubMed PMID: WOS:000338488800028
  143. Carney CM, Muszynski JL, Strotman LN, Lewis SR, O’Connell RL, Beebe DJ, Theberge AB, Jorgensen JS. Cellular microenvironment dictates androgen production by murine fetal leydig cells in primary culture. Biol Reprod. 2014;91(4):85. Epub 2014/08/22. doi: 10.1095/biolreprod.114.118570. PubMed PMID: 25143354
  144. Bischel LL, Sung KE, Jimenez-Torres JA, Mader B, Keely PJ, Beebe DJ. The importance of being a lumen. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014;28(11):4583-90. Epub 2014/08/01. doi: 10.1096/fj.13-243733. PubMed PMID: 25077562; 4200326
  145. Bischel L, Casavant B, Young P, Eliceiri K, Basu H, Beebe D. A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells. Integrative Biology. 2014;6(6):627-35. doi: 10.1039/c3ib40240a. PubMed PMID: WOS:000336835100006
  146. Berthier E, Beebe D. Gradient generation platforms: new directions for an established microfluidic technology. Lab on a Chip. 2014;14(17):3241-7. doi: 10.1039/c4lc00448e. PubMed PMID: WOS:000340204300016
  147. Berry S, Singh C, Lang J, Strotman L, Alarid E, Beebe D. Streamlining gene expression analysis: integration of co-culture and mRNA purification. Integrative Biology. 2014;6(2):224-31. doi: 10.1039/c3ib40136g. PubMed PMID: WOS:000330795500011
  148. Berry S, LaVanway A, Pezzi H, Guckenberger D, Anderson M, Loeb J, Beebe D. HIV Viral RNA Extraction in Wax Immiscible Filtration Assisted by Surface Tension (IFAST) Devices. Journal of Molecular Diagnostics. 2014;16(3):297-304. doi: 10.1016/j.jmoldx.2014.01.004. PubMed PMID: WOS:000335540200003
  149. Berry S, Chin E, Jackson S, Strotman L, Goel M, Thompson N, Alexander C, Miyamoto S, Burgess R, Beebe D. Weak protein-protein interactions revealed by immiscible filtration assisted by surface tension. Analytical Biochemistry. 2014;447:133-40. doi: 10.1016/j.ab.2013.10.038. PubMed PMID: WOS:000330089500022
  150. Young E, Berthier E, Beebe D. Assessment of Enhanced Autofluorescence and Impact on Cell Microscopy for Microfabricated Thermoplastic Devices. Analytical Chemistry. 2013;85(1):44-9. doi: 10.1021/ac3034773. PubMed PMID: WOS:000313156500010
  151. Warrick J, Young E, Schmuck E, Saupe K, Beebe D. High-content adhesion assay to address limited cell samples. Integrative Biology. 2013;5(4):720-7. doi: 10.1039/c3ib20224k. PubMed PMID: WOS:000316692700009
  152. Thomas P, Strotman L, Theberge A, Berthier E, O’Connell R, Loeb J, Berry S, Beebe D. Nucleic Acid Sample Preparation Using Spontaneous Biphasic Plug Flow. Analytical Chemistry. 2013;85(18):8641-6. doi: 10.1021/ac4012914. PubMed PMID: WOS:000330017400024
  153. Sung K, Su X, Berthier E, Pehlke C, Friedl A, Beebe D. Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models. Plos One. 2013;8(10). doi: 10.1371/journal.pone.0076373. PubMed PMID: WOS:000325489100107
  154. Su X, Theberge A, January C, Beebe D. Effect of Microculture on Cell Metabolism and Biochemistry: Do Cells Get Stressed in Microchannels? Analytical Chemistry. 2013;85(3):1562-70. doi: 10.1021/ac3027228. PubMed PMID: WOS:000314676100047
  155. Strotman L, O’Connell R, Casavant B, Berry S, Sperger J, Lang J, Beebe D. Selective Nucleic Acid Removal via Exclusion (SNARE): Capturing mRNA and DNA from a Single Sample. Analytical Chemistry. 2013;85(20):9764-70. doi: 10.1021/ac402162r. PubMed PMID: WOS:000326126600049
  156. Schwartz M, Rogers R, Singh S, Lee J, Loveland S, Koepsel J, Witze E, Montanez-Sauri S, Sung K, Tokuda E, Sharma Y, Everhart L, Nguyen E, Zaman M, Beebe D, Ahn N, Murphy W, Anseth K. A Quantitative Comparison of Human HT-1080 Fibrosarcoma Cells and Primary Human Dermal Fibroblasts Identifies a 3D Migration Mechanism with Properties Unique to the Transformed Phenotype. Plos One. 2013;8(12). doi: 10.1371/journal.pone.0081689. PubMed PMID: WOS:000327947800054
  157. Moussavi-Harami S, Annis D, Ma W, Berry S, Coughlin E, Strotman L, Maurer L, Westphall M, Coon J, Mosher D, Beebe D. Characterization of Molecules Binding to the 70K N-Terminal Region of Fibronectin by IFAST Purification Coupled with Mass Spectrometry. Journal of Proteome Research. 2013;12(7):3393-404. doi: 10.1021/pr400225p. PubMed PMID: WOS:000321605700030
  158. Montanez-Sauri S, Sung K, Berthier E, Beebe D. Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. Integrative Biology. 2013;5(3):631-40. doi: 10.1039/c3ib20225a. PubMed PMID: WOS:000315354900018
  159. Lang J, Casavant B, Berry S, Strotman L, Thiede S, Sperger J, Liu G, Beebe D. Nuclear localization of the androgen receptor in prostate cancer circulating tumor cells from men who have failed androgen deprivation therapy. Journal of Clinical Oncology. 2013;31(15). PubMed PMID: WOS:000335419605265
  160. Lang J, Berry S, Powers G, Beebe D, Alarid E. Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity. Integrative Biology. 2013;5(5):807-16. doi: 10.1039/c3ib20265h. PubMed PMID: WOS:000318302100006
  161. Hong W, Young E, Tepp W, Johnson E, Beebe D. A Microscale Neuron and Schwann Cell Coculture Model for Increasing Detection Sensitivity of Botulinum Neurotoxin Type A. Toxicological Sciences. 2013;134(1):64-72. doi: 10.1093/toxsci/kft082. PubMed PMID: WOS:000320907900006
  162. Casavant B, Mosher R, Warrick J, Maccoux L, Berry S, Becker J, Chen V, Lang J, McNeel D, Beebe D. A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells. Methods. 2013;64(2):137-43. doi: 10.1016/j.ymeth.2013.05.027. PubMed PMID: WOS:000327567400007
  163. Casavant B, Guckenberger D, Berry S, Tokar J, Lang J, Beebe D. The VerIFAST: an integrated method for cell isolation and extracellular/intracellular staining. Lab on a Chip. 2013;13(3):391-6. doi: 10.1039/c2lc41136a. PubMed PMID: WOS:000312947300010
  164. Casavant B, Berthier E, Theberge A, Berthier J, Montanez-Sauri S, Bischel L, Brakke K, Hedman C, Bushman W, Keller N, Beebe D. Suspended microfluidics. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(25):10111-6. doi: 10.1073/pnas.1302566110. PubMed PMID: WOS:000321500200030
  165. Bischel L, Young E, Mader B, Beebe D. Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. Biomaterials. 2013;34(5):1471-7. doi: 10.1016/j.biomaterials.2012.11.005. PubMed PMID: WOS:000313929400003
  166. Bischel L, Mader B, Green J, Huttenlocher A, Beebe D. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab on a Chip. 2013;13(9):1732-6. doi: 10.1039/c3lc50099c. PubMed PMID: WOS:000316962700009
  167. Berthier E, Lim F, Deng Q, Guo C, Kontoyiannis D, Wang C, Rindy J, Beebe D, Huttenlocher A, Keller N. Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites. Plos Pathogens. 2013;9(4). doi: 10.1371/journal.ppat.1003289. PubMed PMID: WOS:000318072700030
  168. Berthier E, Guckenberger D, Cavnar P, Huttenlocher A, Keller N, Beebe D. Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab on a Chip. 2013;13(3):424-31. doi: 10.1039/c2lc41019b. PubMed PMID: WOS:000312947300014
  169. Berry S, Regehr K, Casavant B, Beebe D. Automated Operation of Immiscible Filtration Assisted by Surface Tension (IFAST) Arrays for Streamlined Analyte Isolation. Jala. 2013;18(3):206-11. doi: 10.1177/2211068212462023. PubMed PMID: WOS:000325923700003
  170. Beebe D, Ingber D, den Toonder J. Organs on Chips 2013. Lab on a Chip. 2013;13(18):3447-8. doi: 10.1039/c3lc90080k. PubMed PMID: WOS:000323111300001
  171. Young E, Pak C, Kahl B, Yang D, Callander N, Miyamoto S, Beebe D. e-Blood Microscale functional cytomics for studying hematologic cancers. Blood. 2012;119(10):E76-E85. doi: 10.1182/blood-2011-10-384347. PubMed PMID: WOS:000301356000002
  172. Su G, Sung K, Beebe D, Friedl A. Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts. Plos One. 2012;7(10). doi: 10.1371/journal.pone.0046685. PubMed PMID: WOS:000309831500057
  173. Strotman L, Lin G, Berry S, Johnson E, Beebe D. Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension). Analyst. 2012;137(17):4023-8. doi: 10.1039/c2an35506j. PubMed PMID: WOS:000306932400022
  174. Sackmann E, Berthier E, Young E, Shelef M, Wernimont S, Huttenlocher A, Beebe D. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012;120(14):E45-E53. doi: 10.1182/blood-2012-03-416453. PubMed PMID: WOS:000311616900001
  175. Resto P, Berthier E, Beebe D, Williams J. An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices. Lab on a Chip. 2012;12(12):2221-8. doi: 10.1039/c2lc20858j. PubMed PMID: WOS:000304448700015
  176. Lee J, Kim Y, Beebe D, Kim B. Harnessing gravitational, hydrodynamic and negative dielectrophoretic forces for higher throughput cell sorting. Biochip Journal. 2012;6(3):229-39. doi: 10.1007/s13206-012-6305-2. PubMed PMID: WOS:000308779800005
  177. Lee A, Beebe D, Palecek S. Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels. Biomedical Microdevices. 2012;14(2):247-57. doi: 10.1007/s10544-011-9602-y. PubMed PMID: WOS:000301544500001
  178. Lang J, Casavant B, Beebe D. Circulating Tumor Cells: Getting More from Less. Science Translational Medicine. 2012;4(141). doi: 10.1126/scitranslmed.3004261. PubMed PMID: WOS:000306108800002
  179. Guckenberger D, Berthier E, Young E, Beebe D. Induced hydrophobic recovery of oxygen plasma-treated surfaces. Lab on a Chip. 2012;12(13):2317-21. doi: 10.1039/c2lc21052e. PubMed PMID: WOS:000305288600006
  180. Goel S, Chin E, Fakhraldeen S, Berry S, Beebe D, Alexander C. Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts. Journal of Biological Chemistry. 2012;287(20):16454-66. doi: 10.1074/jbc.M112.362137. PubMed PMID: WOS:000304030900036
  181. Domenech M, Bjerregaard R, Bushman W, Beebe D. Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integrative Biology. 2012;4(2):142-52. doi: 10.1039/c1ib00104c. PubMed PMID: WOS:000299640700003
  182. Cavnar P, Mogen K, Berthier E, Beebe D, Huttenlocher A. The Actin Regulatory Protein HS1 Interacts with Arp2/3 and Mediates Efficient Neutrophil Chemotaxis. Journal of Biological Chemistry. 2012;287(30):25466-77. doi: 10.1074/jbc.M112.364562. PubMed PMID: WOS:000306651700053
  183. Casavant B, Tokar J, Lang J, Abel E, Beebe D. Isolation of renal cell carcinoma cells from blood samples using the vertical immiscible filtration assisted by surface tension (VerIFAST) microfluidic platform. Bju International. 2012;110:3-. PubMed PMID: WOS:000308932400007
  184. Bischel L, Lee S, Beebe D. A Practical Method for Patterning Lumens through ECM Hydrogels via Viscous Finger Patterning. Jala. 2012;17(2):96-103. doi: 10.1177/2211068211426694. PubMed PMID: WOS:000304775300002
  185. Berry S, Maccoux L, Beebe D. Streamlining Immunoassays with Immiscible Filtrations Assisted by Surface Tension. Analytical Chemistry. 2012;84(13):5518-23. doi: 10.1021/ac300085m. PubMed PMID: WOS:000305871300012
  186. Young E, Berthier E, Guckenberger D, Sackmann E, Lamers C, Meyvantsson I, Huttenocher A, Beebe D. Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays. Analytical Chemistry. 2011;83(4):1408-17. doi: 10.1021/ac102897h. PubMed PMID: WOS:000287176900037
  187. Sung K, Yang N, Pehlke C, Keely P, Eliceiri K, Friedl A, Beebe D. Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integrative Biology. 2011;3(4):439-50. doi: 10.1039/c0ib00063a. PubMed PMID: WOS:000289154600016
  188. Su X, Young E, Underkofler H, Kamp T, January C, Beebe D. Microfluidic Cell Culture and Its Application in High-Throughput Drug Screening: Cardiotoxicity Assay for hERG Channels. Journal of Biomolecular Screening. 2011;16(1):101-11. doi: 10.1177/1087057110386218. PubMed PMID: WOS:000286063300011
  189. Montanez-Sauri S, Sung K, Puccinelli J, Pehlke C, Beebe D. Automation of Three-Dimensional Cell Culture in Arrayed Microfluidic Devices. Jala. 2011;16(3):171-85. doi: 10.1016/j.jala.2011.02.003. PubMed PMID: WOS:000290826000002
  190. Kshitiz, Kim D, Beebe D, Levchenko A. Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends in Biotechnology. 2011;29(8):399-408. doi: 10.1016/j.tibtech.2011.03.006. PubMed PMID: WOS:000293485300005
  191. Frisk M, Lin G, Johnson E, Beebe D. Synaptotagmin II peptide-bead conjugate for botulinum toxin enrichment and detection in microchannels. Biosensors & Bioelectronics. 2011;26(5):1929-35. doi: 10.1016/j.bios.2010.06.035. PubMed PMID: WOS:000286904400022
  192. Cavnar P, Berthier E, Beebe D, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. Journal of Cell Biology. 2011;193(3):465-73. doi: 10.1083/jcb.201010143. PubMed PMID: WOS:000290676400007
  193. Berthier E, Warrick J, Casavant B, Beebe D. Pipette-friendly laminar flow patterning for cell-based assays. Lab on a Chip. 2011;11(12):2060-5. doi: 10.1039/c0lc00539h. PubMed PMID: WOS:000291166000015
  194. Berry S, Strotman L, Kueck J, Alarid E, Beebe D. Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomedical Microdevices. 2011;13(6):1033-42. doi: 10.1007/s10544-011-9573-z. PubMed PMID: WOS:000297121700009
  195. Berry S, Alarid E, Beebe D. One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST). Lab on a Chip. 2011;11(10):1747-53. doi: 10.1039/c1lc00004g. PubMed PMID: WOS:000289951200006
  196. Young E, Beebe D. Fundamentals of microfluidic cell culture in controlled microenvironments. Chemical Society Reviews. 2010;39(3):1036-48. doi: 10.1039/b909900j. PubMed PMID: WOS:000274920300012
  197. Puccinelli J, Su X, Beebe D. Automated High-Throughput Microchannel Assays for Cell Biology: Operational Optimization and Characterization. Jala. 2010;15(1):25-32. doi: 10.1016/j.jala.2009.10.002. PubMed PMID: WOS:000295434000004
  198. Paguirigan A, Puccinelli J, Su X, Beebe D. Expanding the Available Assays: Adapting and Validating In-Cell Westerns in Microfluidic Devices for Cell-Based Assays. Assay and Drug Development Technologies. 2010;8(5):591-601. doi: 10.1089/adt.2010.0274. PubMed PMID: WOS:000283438400006
  199. Lopez-Garcia M, Beebe D, Crone W. Mechanical Interactions of Mouse Mammary Gland Cells with Collagen in a Three-Dimensional Construct. Annals of Biomedical Engineering. 2010;38(8):2485-98. doi: 10.1007/s10439-010-0015-5. PubMed PMID: WOS:000279682000002
  200. Lopez-Garcia M, Beebe D, Crone W. Young’s modulus of collagen at slow displacement rates. Bio-Medical Materials and Engineering. 2010;20(6):361-9. doi: 10.3233/bme-2010-0649. PubMed PMID: WOS:000286596200006
  201. Lee A, Arena C, Beebe D, Palecek S. Macroporous hydrogels for quantifying cancer-inducing kinase activity in microfluidic devices. Abstracts of Papers of the American Chemical Society. 2010;239. PubMed PMID: WOS:000208189300681
  202. Lee A, Arena C, Beebe D, Palecek S. Development of Macroporous Poly(ethylene glycol) Hydrogel Arrays within Microfluidic Channels. Biomacromolecules. 2010;11(12):3316-24. doi: 10.1021/bm100792y. PubMed PMID: WOS:000285267500012
  203. Ju J, Warrick J, Beebe D. A Cell Programmable Assay (CPA) chip. Lab on a Chip. 2010;10(16):2071-6. doi: 10.1039/c005103a. PubMed PMID: WOS:000280394800008
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  205. Beebe D, Huttenlocher A. Introduction to the Mechanisms of Directed Cell Migration themed issue. Integrative Biology. 2010;2(11-12):559-60. doi: 10.1039/c0ib90017f. PubMed PMID: WOS:000283741400001
  206. Bauer M, Su G, Beebe D, Friedl A. 3D microchannel co-culture: method and biological validation. Integrative Biology. 2010;2(7-8):371-8. doi: 10.1039/c0ib00001a. PubMed PMID: WOS:000280769200006
  207. Zhu Y, Warrick J, Haubert K, Beebe D, Yin J. Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomedical Microdevices. 2009;11(3):565-70. doi: 10.1007/s10544-008-9263-7. PubMed PMID: WOS:000265440300005
  208. Sung K, Su G, Pehlke C, Trier S, Eliceiri K, Keely P, Friedl A, Beebe D. Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials. 2009;30(27):4833-41. doi: 10.1016/j.biomaterials.2009.05.043. PubMed PMID: WOS:000269330400045
  209. Regehr K, Domenech M, Koepsel J, Carver K, Ellison-Zelski S, Murphy W, Schuler L, Alarid E, Beebe D. Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab on a Chip. 2009;9(15):2132-9. doi: 10.1039/b903043c. PubMed PMID: WOS:000268033900003
  210. Paguirigan A, Beebe D. From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integrative Biology. 2009;1(2):182-95. doi: 10.1039/b814565b. PubMed PMID: WOS:000267113600005
  211. Mohanty S, Warrick J, Gorski J, Beebe D. An accessible micro-capillary electrophoresis device using surface-tension-driven flow. Electrophoresis. 2009;30(9):1470-81. doi: 10.1002/elps.200800595. PubMed PMID: WOS:000266312800006
  212. Kim D, Lokuta M, Huttenlocher A, Beebe D. Selective and tunable gradient device for cell culture and chemotaxis study. Lab on a Chip. 2009;9(12):1797-800. doi: 10.1039/b901613a. PubMed PMID: WOS:000266616000021
  213. Khnouf R, Beebe D, Fan Z. Cell-free protein expression in a microchannel array with passive pumping. Lab on a Chip. 2009;9(1):56-61. doi: 10.1039/b808034h. PubMed PMID: WOS:000262649400009
  214. Frisk M, Tepp W, Johnson E, Beebe D. Self-Assembled Peptide Monolayers as a Toxin Sensing Mechanism within Arrayed Microchannels. Analytical Chemistry. 2009;81(7):2760-7. doi: 10.1021/ac802707u. PubMed PMID: WOS:000264759400046
  215. Domenech M, Yu H, Warrick J, Badders N, Meyvantsson I, Alexander C, Beebe D. Cellular observations enabled by microculture: paracrine signaling and population demographics. Integrative Biology. 2009;1(3):267-74. doi: 10.1039/b823059e. PubMed PMID: WOS:000267113900005
  216. Beebe D, Barcellos-Hoff M. The development of integrative biology: bridging the gap-a view from the Scientific Editors. Integrative Biology. 2009;1(2):145-7. doi: 10.1039/b822329g. PubMed PMID: WOS:000267113600001
  217. Paguirigan A, Beebe D. Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. Bioessays. 2008;30(9):811-21. doi: 10.1002/bies.20804. PubMed PMID: WOS:000258891400005
  218. Meyvantsson I, Warrick J, Hayes S, Skoien A, Beebe D. Automated cell culture in high density tubeless microfluidic device arrays. Lab on a Chip. 2008;8(5):717-24. doi: 10.1039/b715375a. PubMed PMID: WOS:000255276700012
  219. Meyvantsson I, Beebe D. Cell Culture Models in Microfluidic Systems. Annual Review of Analytical Chemistry. 2008;1:423-49. doi: 10.1146/annurev.anchem.1.031207.113042. PubMed PMID: WOS:000262525200014
  220. Lopez-Garcia M, Monson R, Haubert K, Wheeler M, Beebe D. Sperm motion in a microfluidic fertilization device. Biomedical Microdevices. 2008;10(5):709-18. doi: 10.1007/s10544-008-9182-7. PubMed PMID: WOS:000258581700012
  221. Kwon G, Park J, Kim J, Frisk M, Beebe D, Lee S. Biomimetic Soft Multifunctional Miniature Aquabots. Small. 2008;4(12):2148-53. doi: 10.1002/smll.200800315. PubMed PMID: WOS:000261905100012
  222. Kim D, Beebe D. Interfacial formation of porous membranes with poly(ethylene glycol) in a microfluidic environment. Journal of Applied Polymer Science. 2008;110(3):1581-9. doi: 10.1002/app.27890. PubMed PMID: WOS:000259168100038
  223. Ju J, Park J, Kim K, Kim H, Berthier E, Beebe D, Lee S. Backward flow in a surface tension driven micropump. Journal of Micromechanics and Microengineering. 2008;18(8). doi: 10.1088/0960-1317/18/8/087002. PubMed PMID: WOS:000257891600023
  224. Jongpaiboonkit L, King W, Lyons G, Paguirigan A, Warrick J, Beebe D, Murphy W. An adaptable hydrogel array format for 3-dimensional cell culture and analysis. Biomaterials. 2008;29(23):3346-56. doi: 10.1016/j.biomaterials.2008.04.040. PubMed PMID: WOS:000257344600007
  225. Frisk M, Berthier E, Tepp W, Johnson E, Beebe D. Bead-based microfluidic toxin sensor integrating evaporative signal amplification. Lab on a Chip. 2008;8(11):1793-800. doi: 10.1039/b811075a. PubMed PMID: WOS:000261686100010
  226. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays – Part 2. Characterization of convection and diffusion for cell biology. Lab on a Chip. 2008;8(6):860-4. doi: 10.1039/b717423c. PubMed PMID: WOS:000256115200002
  227. Berthier E, Warrick J, Yu H, Beebe D. Managing evaporation for more robust microscale assays – Part 1. Volume loss in high throughput assays. Lab on a Chip. 2008;8(6):852-9. doi: 10.1039/b717422e. PubMed PMID: WOS:000256115200001
  228. Badders N, Yu H, Alexander C, Beebe D. Quantification of small cell numbers with a microchannel device. Biotechniques. 2008;45(3):321-+. doi: 10.2144/000112906. PubMed PMID: WOS:000263638100023
  229. Abhyankar V, Toepke M, Cortesio C, Lokuta M, Huttenlocher A, Beebe D. A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab on a Chip. 2008;8(9):1507-15. doi: 10.1039/b803533d. PubMed PMID: WOS:000259676000013
  230. Zheng T, Yu H, Alexander C, Beebe D, Smith L. Lectin-modified microchannels for mammalian cell capture and purification. Biomedical Microdevices. 2007;9(4):611-7. doi: 10.1007/s10544-007-9074-2. PubMed PMID: WOS:000248007500020
  231. Yu H, Alexander C, Beebe D. Understanding microchannel culture: parameters involved in soluble factor signaling. Lab on a Chip. 2007;7(6):726-30. doi: 10.1039/b618793e. PubMed PMID: WOS:000247566400020
  232. Yu H, Alexander C, Beebe D. A plate reader-compatible microchannel array for cell biology assays. Lab on a Chip. 2007;7(3):388-91. doi: 10.1039/b612358a. PubMed PMID: WOS:000244616900014
  233. Wheeler M, Walters E, Beebe D. Toward culture of single gametes: The development of microfluidic platforms for assisted reproduction. Theriogenology. 2007;68:S178-S89. doi: 10.1016/j.theriogenology.2007.04.042|10.1016/i.theriogenology.2007.04.042. PubMed PMID: WOS:000248916700023
  234. Warrick J, Meyvantsson I, Ju J, Beebe D. High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab on a Chip. 2007;7(3):316-21. doi: 10.1039/b613350a. PubMed PMID: WOS:000244616900004
  235. Toepke M, Abhyankar V, Beebe D. Microfluidic logic gates and timers. Lab on a Chip. 2007;7(11):1449-53. doi: 10.1039/b708764k. PubMed PMID: WOS:000250428200016
  236. Paguirigan A, Beebe D, Alexander C. Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity. Cell Proliferation. 2007;40(1):106-24. PubMed PMID: WOS:000243442600009
  237. Paguirigan A, Beebe D. Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nature Protocols. 2007;2(7):1782-8. doi: 10.1038/nprot.2007.256. PubMed PMID: WOS:000253139200024
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